Poly-GA immunohistochemistry is a reliable tool for detecting C9orf72 hexanucleotide repeat expansions

IF 5.8 2区医学 Q1 CLINICAL NEUROLOGY

Brain Pathology Pub Date : 2023-10-10 DOI:10.1111/bpa.13216

Jordan Carroll, Heather McCann, Glenda M. Halliday, John B. Kwok, Carol Dobson-Stone, Claire E. Shepherd

引用次数: 0

Abstract

Poly-GA immunohistochemistry (A) on formalin fixed paraffin embedded cerebellum sections shows a similar distribution to p62 antibody (B) and reliably identifies neuronal cytoplasmic inclusions and neurites in cases with known C9orf72 repeat expansion. This is useful in the research setting where genetic testing has not been performed in life or suitable tissue is not avilable post-mortem.

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Poly-GA免疫组织化学是检测C9orf72六核苷酸重复扩增的可靠工具。

福尔马林固定石蜡包埋的小脑切片上的Poly-GA免疫组织化学（A）显示出与p62抗体（B）相似的分布，并在已知C9orf72重复扩增的情况下可靠地识别神经元细胞质内含物和轴突。这在研究环境中很有用，因为在生活中没有进行基因检测，或者死后没有合适的组织。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Pathology 医学-病理学

CiteScore

13.20

自引率

3.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Brain Pathology is the journal of choice for biomedical scientists investigating diseases of the nervous system. The official journal of the International Society of Neuropathology, Brain Pathology is a peer-reviewed quarterly publication that includes original research, review articles and symposia focuses on the pathogenesis of neurological disease.