Incidence of depression in patients with cardiovascular disease and type 2 diabetes: a nationwide cohort study.

IF 3.8 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Clinical Research in Cardiology Pub Date : 2024-11-01 Epub Date: 2023-10-10 DOI:10.1007/s00392-023-02311-3

Bochra Zareini, Katrine Kold Sørensen, Paul Blanche, Alexander C Falkentoft, Emil Fosbøl, Lars Køber, Christian Torp-Pedersen

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引用次数: 0

Abstract

Background: Estimating how type 2 diabetes (T2D) affects the rate of depression in cardiovascular disease (CVD) can help identify high-risk patients. The aim is to investigate how T2D affects the rate of depression according to specific subtypes of CVD.

Methods: Incident CVD patients, free of psychiatric disease, with and without T2D, were included from nationwide registries between 2010 and 2020. We followed patients from CVD diagnosis until the first occurrence of depression, emigration, death, 5 years, or end of study (December 31, 2021). We used time-dependent Poisson regression to estimate the incidence rates and rate ratios (IRR) of depression following subtypes of CVD with and without T2D. The model included age, sex, comorbidities, calendar year, T2D duration, educational level, and living situation as covariates.

Results: A total of 165,096 patients were included; 45,845 had a myocardial infarction (MI), 63,691 had a stroke, 19,959 had peripheral artery disease (PAD), 35,568 had heart failure (HF), and 979 were diagnosed with 2 or more CVD subtypes (= > 2 CVD's). Baseline T2D in each CVD subtype ranged from 11 to 17%. The crude incidence rate of depression per 1000 person-years (95% confidence intervals) was: MI + T2D: 131.1 (109.6;155.6), MI: 82.1 (65.3;101.9), stroke + T2D: 287.4 (255.1;322.6), stroke: 222.4(194.1;253.6), PAD + T2D: 173.6 (148.7;201.4), PAD:137.5 (115.5;162.5), HF + T2D: 244.3 (214.6;276.9), HF: 199.2 (172.5;228.9), = > 2 CVD's + T2D: 427.7 (388.1;470.2), = > 2 CVD's: 372.1 (335.2;411.9). The adjusted IRR of depression in MI, stroke, PAD, HF, and = > 2 CVD's with T2D compared to those free of T2D was: 1.29 (1.23;1.35), 1.09 (1.06;1.12), 1.18 (1.13;1.24), 1.05 (1.02;1.09), and 1.04 (0.85;1.27) (p-value for interaction < 0.001).

Conclusion: The presence of T2D increased the rate of depression differently among CVD subtypes, most notable in patients with MI and PAD.

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心血管疾病和2型糖尿病患者的抑郁症发病率：一项全国性队列研究。

背景：估计2型糖尿病（T2D）如何影响心血管疾病（CVD）的抑郁率有助于识别高危患者。目的是根据心血管疾病的特定亚型，研究T2D如何影响抑郁症的发病率。方法：2010年至2020年间，从全国登记处纳入无精神疾病、有T2D和无T2D的心血管疾病患者。我们对从CVD诊断到首次出现抑郁症、移民、死亡、5年或研究结束（2021年12月31日）的患者进行了随访。我们使用时间依赖性泊松回归来估计患有和不患有T2D的CVD亚型的抑郁症的发病率和发病率比（IRR）。该模型包括年龄、性别、合并症、日历年、T2D持续时间、教育水平和生活状况作为协变量。结果：共纳入165096例患者；45845人患有心肌梗死（MI），63691人患有中风，19959人患有外周动脉疾病（PAD），35568人患有心力衰竭（HF），979人被诊断为2种或2种以上CVD亚型(= > 2 CVD）。每种CVD亚型的基线T2D范围为11%至17%。每1000人年抑郁症的粗发病率（95%置信区间）为：MI + T2D:131.1（109.6；155.6），MI：82.1（65.3；101.9），中风 + T2D:287.4（255.1；322.6），冲程：222.4（194.1；253.6），PAD + T2D:173.6（148.7；201.4），衬垫：137.5（115.5；162.5），HF + T2D:244.3（214.6；276.9），HF:99.2（172.5；228.9）， = > 2 CVD + T2D:427.7（388.1；470.2）， = > 2 CVD：372.1（335.2；411.9）。MI、中风、PAD、HF和 = > 2个患有T2D的CVD与没有T2D的相比为：1.29（1.23；1.35）、1.09（1.06；1.12）、1.18（1.13；1.24）、1.05（1.02；1.09）和1.04（0.85；1.27）（相互作用的p值结论：T2D的存在不同程度地增加了CVD亚型的抑郁率，在MI和PAD患者中最为显著。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Research in Cardiology 医学-心血管系统

CiteScore

11.40

自引率

4.00%

发文量

140

审稿时长

4-8 weeks

期刊介绍： Clinical Research in Cardiology is an international journal for clinical cardiovascular research. It provides a forum for original and review articles as well as critical perspective articles. Articles are only accepted if they meet stringent scientific standards and have undergone peer review. The journal regularly receives articles from the field of clinical cardiology, angiology, as well as heart and vascular surgery. As the official journal of the German Cardiac Society, it gives a current and competent survey on the diagnosis and therapy of heart and vascular diseases.