The effect of silver nanoparticles in addition to sodium fluoride on remineralization of artificial root dentin caries

IF 1.9 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Australian dental journal Pub Date : 2023-10-09 DOI:10.1111/adj.12985

P Kongyodsueb, S Poolthong, S Chumprasert, P Sae-ear, Y Tantilertanant

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Abstract

Background

Silver nanoparticle was developed to overcome the drawback of silver diamine fluoride. However, evidence is limited, especially in root caries. The aim of this study was to evaluate the remineralization effect of silver nanoparticles on root caries.

Materials and Methods

Fifty-five root human dentin slices size 5 × 5 mm² from patients aged over 60 years old were immersed in demineralized solution to create artificial caries. Specimens were allocated into five groups according to the remineralizing agents: silver diamine fluoride (SDF), silver nanoparticles solution (AgNPs), silver nanoparticle solution followed by sodium fluoride varnish (AgNPs+NaF), sodium fluoride varnish (NaF), and tap water. After 8 days of pH-cycling challenge, the microhardness test, lesion depth evaluation, dentin surface morphology, and elemental analysis were performed. Data was analysed using F-test One-way ANOVA followed by Tukey's post hoc test and paired T-test.

Results

All test groups demonstrated a significantly higher microhardness value and lower lesion depth compared with the control group. AgNPs+NaF and NaF-treated groups showed lower efficacy than SDF. Crystal precipitation was presented in all groups composed of silver.

Conclusion

Addition of fluoride varnish did not benefit for silver nanoparticles in preventing further demineralization. SDF provides the highest effectiveness in elderly root carious dentin.

查看原文本刊更多论文

纳米银和氟化钠对人工根牙本质龋再矿化的影响。

背景：银纳米粒子是为了克服氟化二胺银的缺点而开发的。然而，证据有限，尤其是在根龋方面。本研究的目的是评估银纳米颗粒对根龋的再矿化作用。材料和方法：55根人牙本质切片，尺寸5 × 5. 60岁以上患者的mm2 岁的儿童被浸泡在软化溶液中以制造人工龋齿。根据再矿化剂将样品分为五组：氟化二胺银（SDF）、银纳米颗粒溶液（AgNPs）、银纳米粒子溶液，然后是氟化钠清漆（AgNPs+NaF）、氟化钠清漆和自来水。8点之后进行pH循环挑战天数、显微硬度测试、损伤深度评估、牙本质表面形态和元素分析。使用F检验单因素方差分析、Tukey事后检验和配对T检验对数据进行分析。结果：与对照组相比，所有试验组都表现出显著更高的显微硬度值和更低的损伤深度。AgNPs+NaF和NaF处理组的疗效低于SDF。在由银组成的所有组中都出现了晶体沉淀。结论：添加氟清漆对纳米银防止进一步脱矿没有好处。SDF对老年根龋性牙本质的治疗效果最高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Australian dental journal 医学-牙科与口腔外科

CiteScore

4.20

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The Australian Dental Journal provides a forum for the exchange of information about new and significant research in dentistry, promoting the discipline of dentistry in Australia and throughout the world. It comprises peer-reviewed research articles as its core material, supplemented by reviews, theoretical articles, special features and commentaries.