A pattern of cognitive resource disruptions in childhood psychopathology.

IF 3.6 3区医学 Q2 NEUROSCIENCES

Network Neuroscience Pub Date : 2023-10-01 eCollection Date: 2023-01-01 DOI:10.1162/netn_a_00322

Andrew J Stier, Carlos Cardenas-Iniguez, Omid Kardan, Tyler M Moore, Francisco A C Meyer, Monica D Rosenberg, Antonia N Kaczkurkin, Benjamin B Lahey, Marc G Berman

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Abstract

The Hurst exponent (H) isolated in fractal analyses of neuroimaging time series is implicated broadly in cognition. Within this literature, H is associated with multiple mental disorders, suggesting that H is transdimensionally associated with psychopathology. Here, we unify these results and demonstrate a pattern of decreased H with increased general psychopathology and attention-deficit/hyperactivity factor scores during a working memory task in 1,839 children. This pattern predicts current and future cognitive performance in children and some psychopathology in 703 adults. This pattern also defines psychological and functional axes associating psychopathology with an imbalance in resource allocation between fronto-parietal and sensorimotor regions, driven by reduced resource allocation to fronto-parietal regions. This suggests the hypothesis that impaired working memory function in psychopathology follows from a reduced cognitive resource pool and a reduction in resources allocated to the task at hand.

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儿童精神病理学中认知资源破坏的模式。

在神经成像时间序列的分形分析中分离出的Hurst指数（H）与认知有着广泛的联系。在这篇文献中，H与多种精神障碍有关，这表明H与精神病理学有跨维度的联系。在这里，我们将这些结果统一起来，并证明了在1839名儿童的工作记忆任务中，H下降的模式与一般精神病理学和注意力缺陷/多动因子得分的增加有关。这种模式预测了儿童当前和未来的认知表现，并预测了703名成年人的一些精神病理学。这种模式还定义了心理和功能轴，将精神病理学与额顶叶和感觉运动区域之间的资源分配失衡联系起来，这是由额顶叶区域的资源分配减少所驱动的。这表明精神病理学中工作记忆功能受损的假设是由于认知资源库减少和分配给手头任务的资源减少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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