Mental health in patients affected by atopic dermatitis: which effects of treatment with dupilumab?

IF 2.1 3区 医学 Q3 PHARMACOLOGY & PHARMACY
Silvia Mariel Ferrucci, Simona Tavecchio, Gregorio Nicolini, Luisa Angileri, Alessandro Ceresa, Giulia Del Tordello, Emilio Berti, Angelo Valerio Marzano, Massimiliano Buoli
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Abstract

Atopic dermatitis (AD) is an inflammatory skin disease. Patients with AD are prone to develop anxiety and mood disorders. Aim of this study is to investigate if treatment with dupilumab may improve mental health status of patients affected by AD. A total of 66 patients with severe AD were included: 24 subjects were candidate or have just started (one month) treatment with dupilumab, and 42 have been in treatment for one year. 25.8%, 30.3%, and 45.5% of the total sample showed, respectively, clinically significant anxiety, depression, and symptoms of Internet addiction. Patients with anxiety symptoms resulted to have more severe AD, more sleep problems ( P  = 0.028), less quality of life ( P  = 0.001), more severe depressive symptoms ( P  < 0.001), to be more frequently women ( P  = 0.016), to be less frequently treated with dupilumab for one year ( P  = 0.025). Similarly, patients with clinically significant depressive symptoms resulted to have more severe AD, more sleep problems ( P  = 0.003), less quality of life ( P  < 0.001), more severe anxiety symptoms ( P  < 0.001), to be less frequently treated with dupilumab for one year ( P  = 0.008). Patients with AD treated for one year with dupilumab showed a better mental health profile in terms of less severe anxiety and depression with respect to their counterparts.

特应性皮炎患者的心理健康:杜匹单抗治疗有哪些效果?
特应性皮炎(AD)是一种炎症性皮肤病。AD患者容易出现焦虑和情绪障碍。本研究的目的是调查使用杜匹单抗治疗是否可以改善AD患者的心理健康状况。共纳入66名严重AD患者:24名受试者是候选受试者或刚刚开始(一个月)使用杜匹珠单抗治疗,42名已接受一年治疗。25.8%、30.3%和45.5%的总样本分别表现出临床显著的焦虑、抑郁和网络成瘾症状。焦虑症状患者AD加重,睡眠问题增多(P = 0.028),生活质量下降(P = 0.001)、抑郁症状较重(P
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来源期刊
CiteScore
4.40
自引率
23.10%
发文量
97
审稿时长
>12 weeks
期刊介绍: International Clinical Psychopharmacology provides an essential link between research and clinical practice throughout psychopharmacology. It reports on studies in human subjects, both healthy volunteers and patients, which relate the effects of drugs on psychological processes. A major objective of the journal is to publish fully refereed papers which throw light on the ways in which the study of psychotropic drugs can increase our understanding of psychopharmacology. To this end the journal publishes results of early Phase I and II studies, as well as those of controlled clinical trials of psychotropic drugs in Phase II and IV. Other topics covered include the epidemiology of psychotropic drug prescribing and drug taking, the sociology of psychotropic drugs including compliance, and research into the safety and adverse effects of these compounds.
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