Sertoliform endometrioid carcinoma of the right ovary.

IF 0.7 Q4 ENDOCRINOLOGY & METABOLISM
Mohammad Alali, Sulaiman Hajji, Khalid Aljenaee
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引用次数: 0

Abstract

Summary: Endometrioid carcinomas of the ovary are a subtype of epithelial ovarian tumors, with sertoliform endometrioid carcinomas being a rare variant. We report a case of a previously healthy premenopausal woman presenting with androgenic symptoms in the form of hirsutism and male pattern alopecia. On further testing, she was found to have high levels of luteinizing hormone and total testosterone levels, and imaging revealed a large pelvic abdominal mass in the right ovary. She underwent total hysterectomy with bilateral salpingo-oophorectomy. Microscopy and histopathology confirmed the diagnosis of sertoliform endometrioid carcinoma. Her symptoms improved significantly on follow-up. Androgenic tumors might not be common in premenopausal women; however, it is important to maintain a high level of suspicion in patients presenting with virilizing symptoms especially of rapid progression.

Learning points: Our 47-year-old patient presented with virilizing symptoms that were rapidly progressing, which raises the suspicion of an underlying androgen secreting neoplasm. Sertoliform endometrioid carcinoma (SEC) is an extremely rare variant of endometrioid carcinomas and tend to present at an earlier stage as compared to most endometrioid carcinomas of the ovary. Recognition of SEC in virilizing patients is important as it is a well-differentiated, low-grade malignancy with a good prognosis when confined to the ovary.

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右侧卵巢的支持型子宫内膜样癌。
摘要:卵巢子宫内膜样癌是卵巢上皮性肿瘤的一种亚型,其中子宫内膜样子宫内膜癌是一种罕见的变体。我们报告了一例先前健康的绝经前妇女,其表现为多毛症和男性型脱发的雄激素性症状。在进一步的测试中,她被发现黄体生成素和总睾酮水平很高,影像学显示右侧卵巢有一个巨大的盆腔腹部肿块。她接受了全子宫切除术和双侧输卵管卵巢切除术。显微镜和组织病理学证实了子宫内膜样癌的诊断。她的症状在随访中明显改善。雄激素性肿瘤在绝经前妇女中可能并不常见;然而,重要的是,对出现男性化症状的患者保持高度怀疑,尤其是快速进展的患者。学习要点:我们的47岁患者出现男性化症状,进展迅速,这增加了潜在雄激素分泌肿瘤的怀疑。支持型子宫内膜样癌(SEC)是子宫内膜样癌症的一种极为罕见的变体,与大多数卵巢子宫内膜样肿瘤相比,它往往出现在早期。男性化患者对SEC的认识很重要,因为它是一种分化良好、低度恶性肿瘤,局限于卵巢时预后良好。
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来源期刊
CiteScore
1.50
自引率
0.00%
发文量
142
审稿时长
9 weeks
期刊介绍: Endocrinology, Diabetes & Metabolism Case Reports publishes case reports on common and rare conditions in all areas of clinical endocrinology, diabetes and metabolism. Articles should include clear learning points which readers can use to inform medical education or clinical practice. The types of cases of interest to Endocrinology, Diabetes & Metabolism Case Reports include: -Insight into disease pathogenesis or mechanism of therapy - Novel diagnostic procedure - Novel treatment - Unique/unexpected symptoms or presentations of a disease - New disease or syndrome: presentations/diagnosis/management - Unusual effects of medical treatment - Error in diagnosis/pitfalls and caveats
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