The correlation between two potentially antagonistic human adipocytokines, WISP-1 and CTRP1, and their association with insulin resistance.

IF 1.3 4区医学 Q4 ENVIRONMENTAL SCIENCES

Annals of Agricultural and Environmental Medicine Pub Date : 2023-09-28 Epub Date: 2023-09-21 DOI:10.26444/aaem/172122

Małgorzata Mirr, Anna Braszak-Cymerman, Aleksandra Ludziejewska, Matylda Kręgielska-Narożna, Paweł Bogdański, Maciej Owecki

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引用次数: 0

Abstract

Introduction and objective: Wnt-1 signaling pathway protein 1 (WISP-1) and complement-C1q TNF-related protein 1 (CTRP1) are adipokines with possible opposite effects in regulating insulin sensitivity. The study investigated the correlation between circulating WISP-1 and CTRP1 in non-diabetic patients. Correlations between adipokines concentrations and biochemical and anthropometric parameters were also studied.

Material and methods: The cross-sectional study enrolled 107 adult patients without diabetes. Patients with obesity accounted for 52.3% of the study group. Clinical, anthropometric, and laboratory data, including serum levels of WISP-1 and CTRP1, were obtained.

Results: The moderate positive correlation between serum WISP-1 and CTRP1 concentrations was observed (p<0.000001, r=0.49). The correlation was more substantial in non-obese patients than in the obese group (r=0.66 and r=0.36, respectively; p<0.01). Circulating CTRP1 correlated positively with fasting insulin, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), total cholesterol, HDL cholesterol, and LDL cholesterol (p<0.05). WISP-1 level correlated with total cholesterol and HDL cholesterol concentrations (p<0.05). There was no significant difference in WISP-1 and CTRP1 concentrations between the groups with and without insulin resistance. The concentrations of WISP-1 and CTRP1 were significantly higher in females than in males (p<0.05).

Conclusions: WISP-1 and CTRP1 may represent interrelated factors that antagonistically affect insulin resistance.

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两种潜在拮抗性人类脂肪细胞因子WISP-1和CTRP1之间的相关性及其与胰岛素抵抗的关系。

引言和目的：Wnt-1信号通路蛋白1（WISP-1）和补体C1q-TNF相关蛋白1（CTRP1）是一种在调节胰岛素敏感性方面可能具有相反作用的脂肪因子。本研究调查了非糖尿病患者循环中WISP-1和CTRP1之间的相关性。还研究了脂肪因子浓度与生化和人体测量参数之间的相关性。材料和方法：横断面研究纳入了107名无糖尿病的成年患者。肥胖患者占研究组的52.3%。获得临床、人体测量和实验室数据，包括WISP-1和CTRP1的血清水平。结果：血清WISP-1与CTRP1浓度呈中度正相关（P结论：WISP-1和CTRP1可能是拮抗胰岛素抵抗的相关因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Agricultural and Environmental Medicine 医学-公共卫生、环境卫生与职业卫生

CiteScore

3.00

自引率

5.90%

发文量

审稿时长

4-8 weeks

期刊介绍： All papers within the scope indicated by the following sections of the journal may be submitted: Biological agents posing occupational risk in agriculture, forestry, food industry and wood industry and diseases caused by these agents (zoonoses, allergic and immunotoxic diseases). Health effects of chemical pollutants in agricultural areas , including occupational and non-occupational effects of agricultural chemicals (pesticides, fertilizers) and effects of industrial disposal (heavy metals, sulphur, etc.) contaminating the atmosphere, soil and water. Exposure to physical hazards associated with the use of machinery in agriculture and forestry: noise, vibration, dust. Prevention of occupational diseases in agriculture, forestry, food industry and wood industry. Work-related accidents and injuries in agriculture, forestry, food industry and wood industry: incidence, causes, social aspects and prevention. State of the health of rural communities depending on various factors: social factors, accessibility of medical care, etc.