Predictive factors of therapeutic response according to craniofacial skeletal biotype in patients with sleep apnea syndrome using mandibular advancement devices: a pilot study.

Rafael Ecija Navarro, Berşan Karadede, Beyza Karadede Ünal, Domingo Martin Salvador
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Abstract

Objectives: To evaluate the influence of facial biotype in the therapeutic effect of mandibular advancement devices (MADs) according to polysomnographic records in patients diagnosed with sleep apnea-hypopnea syndrome (SAHS).

Materials and methods: A total of 46 patients were recruited. Patients were classified according to facial biotype (mesofacial, brachyfacial, or dolichofacial). The quantitative variables were described as the arithmetic mean and standard deviation or the median and interquartile range. Hypothesis tests used were Pearson's chi-square, paired-sample Student's t- test, the Wilcoxon test, one-way analysis of variance, Kruskal-Wallis test, and Mann-Whitney U-test. P < .05 was considered statistically significant.

Results: A total of 46 patients were categorized into three facial biotype subgroups with no significant differences among them in age, body mass index, neck circumference, and sex. The respiratory disturbance index (RDI) results were as follows: brachyfacial patients had a reduction to 15 events/h (P < .001), the mesofacial patients had a reduction to 14 events/h (P < .001), and the dolichofacial patients did not show a significant reduction. The oxygen desaturation index (ODI) results were as follows: brachyfacial patients had a reduction in ODI episodes to 45 episodes/h (P = .001), mesofacial patients had a reduction to 18 episodes/h (P = .001). In the brachyfacial group, the number of awakenings with MAD therapy was reduced to 23 events/h (P = .003), while, in the mesofacial group, it was reduced to 37 episodes/h (P = .012).

Conclusions: The facial biotype influences the effectiveness of MAD therapy and is considered a good predictive factor.

根据颅面骨骼生物型预测下颌前移装置治疗睡眠呼吸暂停综合征患者疗效的因素:一项初步研究。
目的:根据多导睡眠图记录,评估面部生物类型对诊断为睡眠呼吸暂停低通气综合征(SAHS)患者下颌前移器(MADs)治疗效果的影响。材料和方法:共招募46名患者。根据面部生物类型(中面部、短面部或多面部)对患者进行分类。定量变量被描述为算术平均值和标准差或中位数和四分位间距。使用的假设检验包括皮尔逊卡方检验、配对样本Student t检验、Wilcoxon检验、单向方差分析、Kruskal-Wallis检验和Mann-Whitney U检验。P<0.05被认为具有统计学意义。结果:共有46名患者被分为三个面部生物型亚组,在年龄、体重指数、颈围和性别方面没有显著差异。呼吸障碍指数(RDI)结果如下:近面部患者减少到15次事件/小时(P<0.001),中面部患者减少至14次事件/h(P<.001),而多面部患者没有表现出显著的减少。氧去饱和指数(ODI)结果如下:短脸患者的ODI发作次数减少到45次/h(P=0.001),中脸患者减少到18次/h(P=.001)。在短脸组中,MAD治疗的觉醒次数减少到23次/h(P=0.003),而在中脸组中,减少到37次/小时(P=.012)。结论:面部生物类型影响MAD治疗的有效性,被认为是一个很好的预测因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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