Swine global genomic resources: insights into wild and domesticated populations.

IF 2.7 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Mammalian Genome Pub Date : 2023-12-01 Epub Date: 2023-10-07 DOI:10.1007/s00335-023-10012-5
Neal R Benjamin, Richard P M A Crooijmans, Luke R Jordan, Courtni R Bolt, Lawrence B Schook, Kyle M Schachtschneider, Martien A M Groenen, Alfred L Roca
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引用次数: 0

Abstract

Suids, both domesticated and wild, are found on all continents except for Antarctica and provide valuable food resources for humans in addition to serving as important models for biomedical research. Continuing advances in genome sequencing have allowed researchers to compare the genomes from diverse populations of suids helping to clarify their evolution and dispersal. Further analysis of these samples may provide clues to improve disease resistance/resilience and productivity in domestic suids as well as better ways of classifying and conserving genetic diversity within wild and captive suids. Collecting samples from diverse populations of suids is resource intensive and may negatively impact endangered populations. Here we catalog extensive tissue and DNA samples from suids in collections in both Europe and North America. We include samples that have previously been used for whole genome sequencing, targeted DNA sequencing, RNA sequencing, and reduced representation bisulfite sequencing (RRBS). This work provides an important centralized resource for researchers who wish to access published databases.

Abstract Image

全球猪基因组资源:对野生和驯养种群的深入了解。
水貂,无论是驯养的还是野生的,都分布在除南极洲以外的所有大陆,除了作为生物医学研究的重要模式外,还为人类提供了宝贵的食物资源。基因组测序的不断进步使研究人员能够比较不同自杀群体的基因组,有助于阐明其进化和扩散。对这些样本的进一步分析可能为提高家鼠的抗病性/复原力和生产力提供线索,并为野生和圈养鼠的遗传多样性分类和保护提供更好的方法。从不同的suids种群中采集样本是资源密集型的,可能会对濒危种群产生负面影响。在这里,我们从欧洲和北美收集了大量的自杀组织和DNA样本。我们包括以前用于全基因组测序、靶向DNA测序、RNA测序和减少亚硫酸氢盐代表性测序(RRBS)的样本。这项工作为希望访问已发表数据库的研究人员提供了一个重要的集中资源。
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来源期刊
Mammalian Genome
Mammalian Genome 生物-生化与分子生物学
CiteScore
4.00
自引率
0.00%
发文量
33
审稿时长
6-12 weeks
期刊介绍: Mammalian Genome focuses on the experimental, theoretical and technical aspects of genetics, genomics, epigenetics and systems biology in mouse, human and other mammalian species, with an emphasis on the relationship between genotype and phenotype, elucidation of biological and disease pathways as well as experimental aspects of interventions, therapeutics, and precision medicine. The journal aims to publish high quality original papers that present novel findings in all areas of mammalian genetic research as well as review articles on areas of topical interest. The journal will also feature commentaries and editorials to inform readers of breakthrough discoveries as well as issues of research standards, policies and ethics.
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