NOTCH Signaling Pathway: Occurrence, Mechanism, and NOTCH-Directed Therapy for the Management of Cancer.

IF 2.4 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Cancer Biotherapy and Radiopharmaceuticals Pub Date : 2024-02-01 Epub Date: 2023-10-05 DOI:10.1089/cbr.2023.0023

Lakshmi Kumari, Lopamudra Mishra, Yash Sharma, Kanak Chahar, Mritunjay Kumar, Preeti Patel, Ghanshyam Das Gupta, Balak Das Kurmi

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引用次数: 0

Abstract

It is now well understood that many signaling pathways are vital in carrying out and controlling essential pro-survival and pro-growth cellular functions. The NOTCH signaling pathway, a highly conserved evolutionary signaling pathway, has been thoroughly studied since the discovery of NOTCH phenotypes about 100 years ago in Drosophila melanogaster. Abnormal NOTCH signaling has been linked to the pathophysiology of several diseases, notably cancer. In tumorigenesis, NOTCH plays the role of a "double-edged sword," that is, it may act as an oncogene or as a tumor suppressor gene depending on the nature of the context. However, its involvement in several cancers and inhibition of the same provides targeted therapy for the management of cancer. The use of gamma (γ)-secretase inhibitors and monoclonal antibodies for cancer treatment involved NOTCH receptors inhibition, leading to the possibility of a targeted approach for cancer treatment. Likewise, several natural compounds, including curcumin, resveratrol, diallyl sulfide, and genistein, also play a dynamic role in the management of cancer by inhibition of NOTCH receptors. This review outlines the functions and structure of NOTCH receptors and their associated ligands with the mechanism of the signaling pathway. In addition, it also emphasizes the role of NOTCH-targeted nanomedicine in various cancer treatment strategies.

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NOTCH信号通路：癌症的发生、机制和NOTCH导向治疗。

现在人们已经很清楚，许多信号通路在实现和控制重要的促生存和促生长细胞功能方面至关重要。NOTCH信号通路是一种高度保守的进化信号通路，自大约100年前在黑腹果蝇中发现NOTCH表型以来，已经进行了彻底的研究。异常的NOTCH信号与多种疾病的病理生理学有关，尤其是癌症。在肿瘤发生中，NOTCH扮演着一把“双刃剑”的角色，也就是说，它可能作为致癌基因或抑癌基因，这取决于环境的性质。然而，它对几种癌症的参与和对其的抑制为癌症的管理提供了靶向治疗。使用γ-分泌酶抑制剂和单克隆抗体治疗癌症涉及抑制NOTCH受体，从而有可能采用靶向方法治疗癌症。同样，一些天然化合物，包括姜黄素、白藜芦醇、二烯丙基硫化物和染料木黄酮，也通过抑制NOTCH受体在癌症的管理中发挥着动态作用。这篇综述概述了NOTCH受体及其相关配体的功能和结构以及信号通路的机制。此外，它还强调了NOTCH靶向纳米药物在各种癌症治疗策略中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Biotherapy and Radiopharmaceuticals 医学-核医学

CiteScore

7.80

自引率

2.90%

发文量

审稿时长

3 months

期刊介绍： Cancer Biotherapy and Radiopharmaceuticals is the established peer-reviewed journal, with over 25 years of cutting-edge content on innovative therapeutic investigations to ultimately improve cancer management. It is the only journal with the specific focus of cancer biotherapy and is inclusive of monoclonal antibodies, cytokine therapy, cancer gene therapy, cell-based therapies, and other forms of immunotherapies. The Journal includes extensive reporting on advancements in radioimmunotherapy, and the use of radiopharmaceuticals and radiolabeled peptides for the development of new cancer treatments.