Acute stroke in patients taking an oral anticoagulant: impact of clinical pharmacist's intervention on pharmacovigilance reporting.

IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Acta Clinica Belgica Pub Date : 2023-12-01 Epub Date: 2023-10-16 DOI:10.1080/17843286.2023.2261716
Eve-Marie Thillard, Chloé Rousselière, Johana Béné, François Caparros, Marie Bodenant, Pascal Odou, Sophie Gautier, Bertrand Décaudin
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引用次数: 0

Abstract

Introduction: Ischemic or hemorrhagic stroke can occur to patients treated with oral anticoagulants (OAC), through lack of effectiveness or overdosing.

Objective: To evaluate the impact of clinical pharmacist's intervention on pharmacovigilance (PV) reporting for OAC-treated patients hospitalized for stroke.

Methods: Monocentric prospective study in which a clinical pharmacist's intervention was performed in a stroke unit, with a focus on patients treated by OAC prior admission. A PV report was made with all data collected for cases of stroke suspected to be related to OAC therapy. Data provided by pharmacist were compared with data initially available in the patient's electronic medical records. PV reports with pharmacist intervention were compared to those without.

Results: During the study period, 48 patients were included in the study: 43 (89.6%) ischemic strokes with an embolic or unknown etiology, four hemorrhage strokes (8.33%), and one medication error (2.08%). A clinical pharmacist intervention was performed for 19 patients (39.6%) and provided significant additional data in all of them (100%). The information was related to adherence to treatment for 17 cases (89.5%), OAC's initial prescription date for 11 cases (57.9%) and identifying event(s) that could have interfered with the efficacy of the OAC in five cases (26.3%). For patients with pharmacist intervention, PV reports were significantly more informative in terms of date's introduction of anticoagulant, adherence to treatment, reference to weight change or concomitant event.

Conclusions: clinical pharmacist's intervention with patients taking oral anticoagulants and hospitalized for acute stroke contributes to collect high-quality data for pharmacovigilance reporting.

口服抗凝血剂患者的急性卒中:临床药剂师干预对药物警戒报告的影响。
引言:口服抗凝血剂(OAC)治疗的患者可能因缺乏疗效或服用过量而发生缺血性或出血性中风。目的:评估临床药剂师的干预对OAC治疗的脑卒中住院患者药物警戒(PV)报告的影响。方法:单中心前瞻性研究,临床药剂师在中风病房进行干预,重点关注入院前接受OAC治疗的患者。PV报告收集了疑似与OAC治疗相关的中风病例的所有数据。药剂师提供的数据与患者电子医疗记录中最初可用的数据进行了比较。将有药剂师干预的PV报告与没有药剂师干预的报告进行比较。结果:在研究期间,48名患者被纳入研究:43例(89.6%)病因不明的缺血性中风,4例出血性中风(8.33%),1例药物错误(2.08%)。对19例(39.6%)患者进行了临床药剂师干预,并为所有患者(100%)提供了重要的额外数据。这些信息与17例(89.5%)的治疗依从性、11例(57.9%)的OAC初始处方日期以及5例(26.3%)可能干扰OAC疗效的确定事件有关。对于药剂师干预的患者,PV报告在日期引入抗凝剂、治疗依从性,指体重变化或伴随事件。结论:临床药剂师对服用口服抗凝剂和因急性中风住院的患者进行干预,有助于收集高质量的药物警戒报告数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta Clinica Belgica
Acta Clinica Belgica MEDICINE, GENERAL & INTERNAL-
CiteScore
3.50
自引率
0.00%
发文量
44
期刊介绍: Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine primarily publishes papers on clinical medicine, clinical chemistry, pathology and molecular biology, provided they describe results which contribute to our understanding of clinical problems or describe new methods applicable to clinical investigation. Readership includes physicians, pathologists, pharmacists and physicians working in non-academic and academic hospitals, practicing internal medicine and its subspecialties.
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