Differences between bone health parameters in adults with acromegaly and growth hormone deficiency: A systematic review

IF 6.1 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Best practice & research. Clinical endocrinology & metabolism Pub Date : 2023-12-01 DOI:10.1016/j.beem.2023.101824

Pamela U. Freda (Professor of Medicine)

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引用次数: 0

Abstract

Preserving bone health is an important goal of care of patients with acromegaly and growth hormone deficiency (GHD). Both disorders are associated with compromised bone health and an increased risk of fracture. However, parameters of bone health that are routinely used to predict fractures in other populations, such as aBMD measured by DXA, are unreliable for this in acromegaly and GHD. Additional methodologies need to be employed to assess bone health in these patients. This review summarizes available data on the effects of acromegaly and GHD on parameters of bone health such as aBMD, volumetric bone mineral density (vBMD) and microarchitecture assessed by HRpQCT and other techniques, trabecular bone score (TBS) and fracture assessment. More research is needed to identify reliable predictors of fracture risk and to determine how best to screen for and treat those patients at risk so that bone health is optimized in these patients.

查看原文本刊更多论文

成人肢端肥大症和生长激素缺乏症骨健康参数的差异：一项系统综述。

保护骨骼健康是肢端肥大症和生长激素缺乏症（GHD）患者护理的重要目标。这两种疾病都与骨骼健康受损和骨折风险增加有关。然而，通常用于预测其他人群骨折的骨健康参数，如DXA测量的aBMD，在肢端肥大症和GHD中是不可靠的。需要采用其他方法来评估这些患者的骨骼健康状况。这篇综述总结了关于肢端肥大症和GHD对骨健康参数的影响的现有数据，如aBMD、体积骨密度（vBMD）和通过HRpQCT和其他技术评估的微结构、骨小梁评分（TBS）和骨折评估。需要更多的研究来确定骨折风险的可靠预测因素，并确定如何最好地筛查和治疗这些有风险的患者，从而优化这些患者的骨骼健康。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Best practice & research. Clinical endocrinology & metabolism 医学-内分泌学与代谢

CiteScore

11.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Best Practice & Research Clinical Endocrinology & Metabolism is a serial publication that integrates the latest original research findings into evidence-based review articles. These articles aim to address key clinical issues related to diagnosis, treatment, and patient management. Each issue adopts a problem-oriented approach, focusing on key questions and clearly outlining what is known while identifying areas for future research. Practical management strategies are described to facilitate application to individual patients. The series targets physicians in practice or training.