{"title":"Survival of gastric cancer patients in Iran: a systematic review and meta-analysis.","authors":"Fargol Farahmandi, Mohammad-Mahdi Salarabedi, Parynaz Parhizgar, Swetha Variyath, Nabeel Al-Yateem, Syed Azizur Rahman, Amina Al-Marzouqi, Saeed Hashemi Nazari, Alireza Mosavi Jarrahi","doi":"10.22037/ghfbb.v16i2.2674","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to estimate the survival rates among Iranian gastric cancer patients and to evaluate if the survival has improved during the last three decades.</p><p><strong>Background: </strong>Gastric cancer is one of the most common cancers in Iran with high mortality.</p><p><strong>Methods: </strong>A systematic review and meta-analysis of all published studies addressing gastric cancer survival in Iran was performed. International databases of Scopus, Web of Science, PubMed, and Iranian databases were included in the study. The study included databases from their inception till February 2022. Due to the inherent heterogeneity, we used a random effect model to pool the survivals in three categories of one, three, and five-year survivals.</p><p><strong>Results: </strong>Thirty-three studies with total cases of 17,207 were included in the study. The overall (pooled) one, three, and five-year survivals were estimated as 58.9% (95% CI: 0.52, 0.66), 29.9% (95% CI: 0.25, 0.35), and 18.2% (95% CI: 0.15, 0.23), respectively. Results of subgroup analysis for the calendar years of study showed that the one, three, and five-year survival rates increased during the last three decades but the results were not statistically significant. There was the disparity in survival based on geographic distribution.</p><p><strong>Conclusion: </strong>The results of our study which has pooled many studies for a long period of time clearly indicate that the survival rates of gastric cancer patients have improved. As the improvement of survival may be due to many factors, more studies is needed to understand the dynamic behind this improvement.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"16 3","pages":"245-258"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/94/7b/GHFBB-16-245.PMC10520396.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gastroenterology and Hepatology From Bed to Bench","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22037/ghfbb.v16i2.2674","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
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Abstract
Aim: This study aimed to estimate the survival rates among Iranian gastric cancer patients and to evaluate if the survival has improved during the last three decades.
Background: Gastric cancer is one of the most common cancers in Iran with high mortality.
Methods: A systematic review and meta-analysis of all published studies addressing gastric cancer survival in Iran was performed. International databases of Scopus, Web of Science, PubMed, and Iranian databases were included in the study. The study included databases from their inception till February 2022. Due to the inherent heterogeneity, we used a random effect model to pool the survivals in three categories of one, three, and five-year survivals.
Results: Thirty-three studies with total cases of 17,207 were included in the study. The overall (pooled) one, three, and five-year survivals were estimated as 58.9% (95% CI: 0.52, 0.66), 29.9% (95% CI: 0.25, 0.35), and 18.2% (95% CI: 0.15, 0.23), respectively. Results of subgroup analysis for the calendar years of study showed that the one, three, and five-year survival rates increased during the last three decades but the results were not statistically significant. There was the disparity in survival based on geographic distribution.
Conclusion: The results of our study which has pooled many studies for a long period of time clearly indicate that the survival rates of gastric cancer patients have improved. As the improvement of survival may be due to many factors, more studies is needed to understand the dynamic behind this improvement.
目的：本研究旨在评估伊朗癌症患者的生存率，并评估在过去三十年中生存率是否有所改善。背景：癌症是伊朗最常见的癌症之一，死亡率高。方法：对伊朗所有已发表的关于癌症生存率的研究进行系统回顾和荟萃分析。Scopus、Web of Science、PubMed和伊朗数据库的国际数据库也包括在该研究中。这项研究包括从成立到2022年2月的数据库。由于固有的异质性，我们使用随机效应模型将生存率分为一年、三年和五年三类。结果：本研究共纳入33项研究，总病例数为17207例。总的（合并的）一年、三年和五年生存率估计分别为58.9%（95%CI:0.52、0.66）、29.9%（95%CI=0.25、0.35）和18.2%（95%CI:0.15、0.23）。研究日历年的亚组分析结果显示，在过去三十年中，一年、三年和五年的生存率有所上升，但结果没有统计学意义。存在着基于地理分布的生存差异。结论：本研究长期收集了大量研究结果，清楚地表明癌症患者的生存率有所提高。由于生存率的提高可能是由许多因素造成的，因此需要更多的研究来了解这种提高背后的动态。
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