Acquired factor X deficiency in a multiple myeloma without amyloidosis: a case report.

IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Acta Clinica Belgica Pub Date : 2023-12-01 Epub Date: 2023-10-16 DOI:10.1080/17843286.2023.2265650
Amber Coussee, Gudrun Alliet, Anne-Sophie Hervent, Liesbeth Vynckier, Jan Emmerechts, Sam Van Hecke, Lies Persijn
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引用次数: 0

Abstract

Background: Multiple myeloma is one of the most common hematologic malignancies. Acquired factor X deficiencies are often observed in primary (AL) amyloidosis and rarely in multiple myeloma.

Objective: We report a case of an acquired factor X deficiency in a patient with a newly diagnosed IgA lambda multiple myeloma, without any evidence of concomitant amyloidosis.

Methods: We present the patient's medical history, clinical and physical examinations, laboratory analysis, and outcome.

Results: A 76-year-old male presented at the emergency department with ongoing gingival bleeding. Several analytical problems with blood sample analysis arose, which eventually led to the diagnosis of a multiple myeloma. Further exploration revealed an acquired factor X deficiency, explaining the ongoing bleeding. There was no evidence of concomitant amyloidosis. The multiple myeloma was treated, leading to complete remission of the malignancy and bleeding tendency.

Conclusion: While coagulopathy is rarely observed in patients diagnosed with multiple myeloma, considering an acquired factor X deficiency becomes relevant when such patient present with bleeding diathesis.

无淀粉样变性的多发性骨髓瘤获得性X因子缺乏症一例报告。
背景:多发性骨髓瘤是最常见的血液系统恶性肿瘤之一。获得性X因子缺乏常见于原发性(AL)淀粉样变性,很少见于多发性骨髓瘤。目的:我们报告一例新诊断的IgAλ多发性骨髓瘤患者的获得性X因子缺乏症,没有任何伴发淀粉样变性的证据。方法:介绍患者的病史、临床和体格检查、实验室分析和结果。结果:一名76岁男性因牙龈持续出血到急诊科就诊。血液样本分析出现了几个分析问题,最终诊断为多发性骨髓瘤。进一步的探索揭示了后天性X因子缺乏,解释了持续出血的原因。没有伴发淀粉样变性的证据。治疗了多发性骨髓瘤,使恶性肿瘤和出血倾向完全缓解。结论:虽然在诊断为多发性骨髓瘤的患者中很少观察到凝血障碍,但当这些患者具有出血素质时,考虑到获得性X因子缺乏是相关的。
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来源期刊
Acta Clinica Belgica
Acta Clinica Belgica MEDICINE, GENERAL & INTERNAL-
CiteScore
3.50
自引率
0.00%
发文量
44
期刊介绍: Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine primarily publishes papers on clinical medicine, clinical chemistry, pathology and molecular biology, provided they describe results which contribute to our understanding of clinical problems or describe new methods applicable to clinical investigation. Readership includes physicians, pathologists, pharmacists and physicians working in non-academic and academic hospitals, practicing internal medicine and its subspecialties.
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