The Association Between Sleep Duration and Sleep-Related Gene Methylation with Osteoporosis in Chinese Postmenopausal Women.

Rejuvenation research Pub Date : 2023-12-01 Epub Date: 2023-11-08 DOI:10.1089/rej.2023.0045
Qianqian Ma, Ting Liu, Ying Li, Hongyu Xu, Qianqian Xiao, Qi Yao
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Abstract

This study aims to investigate the association between sleep duration and osteoporosis. In addition, sleep-related gene methylation was also detected in this study and we explored its relationship with osteoporosis. The epidemiological investigation section of this study was designed as a retrospective cross-sectional study. We gathered 148 postmenopausal women from two communities and used questionnaires to collect data of sleep duration and other sleep patterns. Biochemical variables were tested, and bone mineral density was measured by dual-energy X-ray absorptiometry. In addition, sleep-related gene (PER2 and PER3) methylation was tested, and the association with osteoporosis was further studied. Twenty-nine of the 148 participants (aged from 65 to 86 years) who suffered from osteoporosis were tested for osteopenia. A significant difference was observed in the association between sleep duration and osteoporosis; the p-value was 0.013. In addition, in our study, we found that short sleep duration (<7 hours) may increase the risk of osteoporosis compared with longer sleep duration. Moreover, sleep-related genes such as PER2 and PER3 and their CpG island methylation were tested, and there was no significant difference between PER2 and PER3 CpG island methylation and osteoporosis. Short sleep duration may increase the risk of osteoporosis. However, the association between sleep-related gene methylation and osteoporosis was not found.

中国绝经后妇女睡眠时间和睡眠相关基因甲基化与骨质疏松症的关系。
目的:探讨睡眠时间与骨质疏松症的关系。此外,本研究还检测了睡眠相关基因甲基化,探讨了其与骨质疏松症的关系。方法:本研究的流行病学调查部分设计为回顾性横断面研究。我们收集了来自两个社区的148名绝经后妇女,并使用问卷收集了睡眠时间和其他睡眠模式的数据。对生化指标进行测试,并用双能X射线吸收法测量骨密度。此外,还检测了睡眠相关基因(PER2和PER3)甲基化,并进一步研究了其与骨质疏松症的关系。结果:在148名参与者中,29名受试者患有骨质疏松症,年龄从65-86岁不等,个体进行了骨质减少测试。睡眠时间与骨质疏松症的相关性有显著差异,P值为0.013。在我们的研究中,我们发现睡眠时间短(结论:睡眠时间短可能会增加患骨质疏松症的风险。但睡眠相关基因甲基化与骨质疏松症之间的关系尚未发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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