ƩexcessA1C index, the sum of yearly excess HbA1c values during the total period of diabetes, may have the potential to predict retinopathy by a linear regression setting regardless of duration in type 1 diabetes: a subgroup analysis of DCCT/EDIC data.

IF 1.3 Q4 ENDOCRINOLOGY & METABOLISM
Diabetology International Pub Date : 2023-08-10 eCollection Date: 2023-10-01 DOI:10.1007/s13340-023-00654-w
Akira Hirose, Yasutaka Maeda, Atsushi Goto, Masae Minami, Shigehiko Kitano, Yasuko Uchigata
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引用次数: 0

Abstract

Aims: To find an index of glycemic exposure that predicts retinopathy by a simple regression setting regardless of duration in type 1 diabetes which might be useful for the care of diabetes.

Materials and methods: To exclude the possible disturbing effect of metabolic memory, we examined a subgroup of patients with glycohemoglobin A1c (A1C) data for the total period of type 1 diabetes selected from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications data. Three indices-(1) mean value of yearly A1C (mA1C), (2) sum of yearly A1C values (ƩA1C), and (3) sum of yearly A1C values above 6.5% (ƩexcessA1C)-were assessed as potential candidates. Development of retinopathy was defined by ≥ 3-steps' progression of retinopathy from baseline.

Results: The areas under the receiver operating characteristics curves of the indices for development of retinopathy at years 5, 9, and 13 after the onset of diabetes were the same: 0.8481, 0.8762, and 0.8213, respectively, indicating that each index was substantially capable of predicting development of retinopathy at each timepoint. Linear regression analyses showed that each index had significant and substantial linear relations to retinopathy at each timepoint: all P < 0.0001 for slopes; contribution rate R2 = 0.21 (year 5), 0.46 (year 9), and 0.48 (year 13) for each index. But only ƩexcessA1C index appeared to have similar linear relations to retinopathy at all three timepoints (interactions by timepoint: for slopes: P = 0.1393; for intercepts: P = 0.9366).

Conclusion: ƩexcessA1C may have the potential to predict retinopathy by just one linear regression setting regardless of duration in type 1 diabetes.

ƩexcessA1C指数,即糖尿病总期间每年过量HbA1c值的总和,可能有可能通过线性回归设置预测1型糖尿病的视网膜病变,无论持续时间如何:DCCT/EDIC数据的亚组分析。
目的:找到一个血糖暴露指数,通过简单的回归设置预测1型糖尿病视网膜病变,而不考虑持续时间,这可能对糖尿病的治疗有用。材料和方法:为了排除代谢记忆可能的干扰作用,我们检查了一组1型糖尿病患者的糖化血红蛋白A1c(A1c)数据,这些数据选自糖尿病控制和并发症试验/糖尿病干预和并发症流行病学数据。三个指标——(1)年A1C平均值(mA1C),(2)年A1C值之和(ƩA1C),和(3)年A1C值之和超过6.5%(\425\ excessA1C)——被评估为潜在候选指标。视网膜病变的发展定义为 ≥ 视网膜病变从基线开始的3步进展。结果:糖尿病发病后第5年、第9年和第13年视网膜病变发展指标的受试者操作特征曲线下面积相同:分别为0.8481、0.8762和0.8213,表明每个指标基本上能够预测每个时间点的视网膜病变发展。线性回归分析表明,各指标在各时间点与视网膜病变呈显著的线性关系:P R2 = 每个指数分别为0.21(第5年)、0.46(第9年)和0.48(第13年)。但只有ƩexcessA1C指数在所有三个时间点似乎与视网膜病变具有相似的线性关系(按时间点的相互作用:斜率:P = 0.1393;对于拦截:P = 0.9366)。结论:ƩexcessA1C可能具有通过一个线性回归设置预测1型糖尿病视网膜病变的潜力,而不考虑持续时间。
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来源期刊
Diabetology International
Diabetology International ENDOCRINOLOGY & METABOLISM-
CiteScore
3.90
自引率
4.50%
发文量
42
期刊介绍: Diabetology International, the official journal of the Japan Diabetes Society, publishes original research articles about experimental research and clinical studies in diabetes and related areas. The journal also presents editorials, reviews, commentaries, reports of expert committees, and case reports on any aspect of diabetes. Diabetology International welcomes submissions from researchers, clinicians, and health professionals throughout the world who are interested in research, treatment, and care of patients with diabetes. All manuscripts are peer-reviewed to assure that high-quality information in the field of diabetes is made available to readers. Manuscripts are reviewed with due respect for the author''s confidentiality. At the same time, reviewers also have rights to confidentiality, which are respected by the editors. The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.
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