Prevalence of Transfusion-transmitted Virus (TTV) Infection and its Association with Renal Post-transplantation Complications in Iran.

IF 0.3 Q4 TRANSPLANTATION

International Journal of Organ Transplantation Medicine Pub Date : 2018-01-01 Epub Date: 2018-08-01

H Akbari, A Piroozmand, E Dadgostar, H Nikoueinejad, Z Chitsazian, B Einollahi, J Amini Mahabadi

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引用次数: 0

Abstract

Background: Transfusion-transmitted virus (TTV) is a single-stranded DNA virus. Renal transplant patients have a higher risk of TTV infection.

Objective: To evaluate the prevalence of TTV and its correlation with post-renal transplantation complications in a population of Iranian patients.

Methods: A cross-sectional study was performed on 120 renal transplant recipients. TTV infection in the peripheral blood samples was detected by semi-nested polymerase chain reaction (semi-nested PCR). Then, the relationship between TTV and renal post-transplant complications was examined.

Results: 34.2% renal transplant recipients were positive for TTV. There was a significant correlation between the presence of TTV and diabetes, acute transplant rejection, and urinary tract infection. We did not find any direct correlation between the presence of TTV infection and hypertension, hyperlipidemia, respiratory tract infection, and cytomegalovirus infection.

Conclusion: We found an increased rate of TTV infection in renal transplant recipients associated with post-transplantation complications. TTV may be an important risk factor for some post-renal transplantation complications.

本刊更多论文

伊朗输血传播病毒（TTV）感染的患病率及其与肾移植后并发症的关系。

背景：输血传播病毒（TTV）是一种单链DNA病毒。肾移植患者感染TTV的风险更高。目的：评估伊朗人群中TTV的患病率及其与肾移植后并发症的相关性。方法：对120例肾移植受者进行横断面研究。采用半巢式聚合酶链反应（semi-nested PCR）检测外周血TTV感染情况。然后，研究TTV与肾移植后并发症之间的关系。结果：肾移植受者TTV阳性率为34.2%。TTV的存在与糖尿病、急性移植排斥反应和尿路感染之间存在显著相关性。我们没有发现TTV感染与高血压、高脂血症、呼吸道感染和巨细胞病毒感染之间有任何直接相关性。结论：我们发现肾移植受者的TTV感染率增加并伴有移植后并发症。TTV可能是一些肾移植术后并发症的重要危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Organ Transplantation Medicine TRANSPLANTATION-

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： The International Journal of Organ Transplantation Medicine (IJOTM) is a quarterly peer-reviewed English-language journal that publishes high-quality basic sciences and clinical research on transplantation. The scope of the journal includes organ and tissue donation, procurement and preservation; surgical techniques, innovations, and novelties in all aspects of transplantation; genomics and immunobiology; immunosuppressive drugs and pharmacology relevant to transplantation; graft survival and prevention of graft dysfunction and failure; clinical trials and population analyses in the field of transplantation; transplant complications; cell and tissue transplantation; infection; post-transplant malignancies; sociological and ethical issues and xenotransplantation.