Introduction to pharmacogenetics.

Q4 Medicine
Drug and Therapeutics Bulletin Pub Date : 2023-11-01 Epub Date: 2023-10-03 DOI:10.1136/dtb.2023.000009
John Henry McDermott, William Newman
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引用次数: 1

Abstract

There is considerable interindividual variability in the effectiveness and safety of medicines. Although the reasons for this are multifactorial, it is well recognised that genetic changes impacting the absorption or metabolism of these drugs play a significant contributory role. Understanding how these pharmacogenetic variants impact response to medicines, and leveraging this knowledge to guide prescribing, could have significant benefits for patients and health services. This article provides an introduction to the field of pharmacogenetics, including its nomenclature, the existing evidence base and the current state of implementation globally. We discuss the challenges in translating pharmacogenetic research into clinical practice and highlight the considerable benefits which can emerge in those health services where implementation is successful.

药物遗传学导论。
药物的有效性和安全性存在相当大的个体差异。尽管造成这种情况的原因是多因素的,但众所周知,影响这些药物吸收或代谢的基因变化起着重要作用。了解这些药物遗传变异如何影响对药物的反应,并利用这些知识指导处方,可能会对患者和医疗服务产生重大益处。本文介绍了药物遗传学领域,包括其命名法、现有证据基础和全球实施现状。我们讨论了将药物遗传学研究转化为临床实践的挑战,并强调了在成功实施的医疗服务中可能出现的巨大好处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Drug and Therapeutics Bulletin
Drug and Therapeutics Bulletin Medicine-Pharmacology (medical)
CiteScore
0.80
自引率
0.00%
发文量
69
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