Prognostic Implications of PRAME Expression and Clinicopathological Factors in Sinonasal Mucosal Melanoma: A Single-center Cohort Study of 30 Cases.

IF 1.6 4区医学 Q4 ONCOLOGY

Anticancer research Pub Date : 2023-10-01 DOI:10.21873/anticanres.16649

Monika Durzynska, Florentino Luciano Caetano Dos Santos, Aldona Matuszczyk, Edyta Derezinska-Wolek, Irmina Maria Michalek

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引用次数: 0

Abstract

Background/aim: Mucosal melanoma (MM) is a rare, aggressive neoplasm in the head and neck region, primarily affecting the nasal cavity and maxillary sinus. This study investigates the correlation of PRAME IHC staining with clinicopathological factors and survival outcomes in sinonasal MM.

Patients and methods: The retrospective cohort included patients diagnosed with melanoma from January 2011 to May 2022. Histopathological reassessment confirmed MM subtype (epithelioid or spindle). IHC testing involved S100, MelanA, HMB45, SOX10, PRAME, BRAF V600E, and pan-TRK. Kaplan-Meier and Cox proportional hazards analyses explored survival probabilities and outcomes.

Results: The cohort comprised 30 patients (17 females, 13 males) with a mean age of 65 years (standard deviation 13). The 5-year survival probability was approximately 32%. Cox analysis revealed male sex and PRAME IHC staining in ≥70% of cells as associated with lower survival probability.

Conclusion: In sinonasal MM, PRAME IHC staining in ≥70% of cells is associated with significantly lower survival probability. Male sex, pN1 stage, and tumor location in the sinus are also predictive of poorer survival outcomes. These findings highlight the potential prognostic significance of PRAME expression and other clinicopathological factors in MM. Further studies are warranted to validate and expand upon these observations.

查看原文本刊更多论文

中国鼻粘膜黑色素瘤PRAME表达和临床病理因素对预后的影响：30例单中心队列研究。

背景/目的：粘膜黑色素瘤（MM）是一种罕见的头颈部侵袭性肿瘤，主要影响鼻腔和上颌窦。本研究调查了PRAME IHC染色与鼻腔MM的临床病理因素和生存结果的相关性。患者和方法：回顾性队列包括2011年1月至2022年5月诊断为黑色素瘤的患者。组织病理学重新评估证实MM亚型（上皮样或梭形）。IHC测试涉及S100、MelanA、HMB45、SOX10、PRAME、BRAF V600E和pan TRK。Kaplan-Meier和Cox比例风险分析探讨了生存概率和结果。结果：该队列包括30名患者（17名女性，13名男性），平均年龄65岁（标准差13）。5年生存概率约为32%。Cox分析显示，男性和PRAME IHC染色在≥70%的细胞中与较低的生存概率有关。结论：在鼻腔MM中，PRAME IHC染色≥70%的细胞存活率显著降低。男性、pN1分期和肿瘤在窦内的位置也预示着较差的生存结果。这些发现强调了PRAME表达和其他临床病理因素在MM中的潜在预后意义。有必要进行进一步的研究来验证和扩展这些观察结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anticancer research 医学-肿瘤学

CiteScore

3.70

自引率

10.00%

发文量

566

审稿时长

2 months

期刊介绍： ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed. ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies). Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.