Impact of Aging and Cellular Senescence in the Pathophysiology of Preeclampsia.

IF 4.2 2区医学 Q1 PHYSIOLOGY

Comprehensive Physiology Pub Date : 2023-09-28 DOI:10.1002/cphy.c230003

Sonja Suvakov, Andrea G Kattah, Tamara Gojkovic, Elizabeth A L Enninga, Jacob Pruett, Muthuvel Jayachandran, Ciria Sousa, Janelle Santos, Coline Abou Hassan, Maria Gonzales-Suarez, Vesna D Garovic

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引用次数: 0

Abstract

The incidence of hypertensive disorders of pregnancy is increasing, which may be due to several factors, including an increased age at pregnancy and more comorbid health conditions during reproductive years. Preeclampsia, the most severe hypertensive disorder of pregnancy, has been associated with an increased risk of future disease, including cardiovascular and kidney diseases. Cellular senescence, the process of cell cycle arrest in response to many physiologic and maladaptive stimuli, may play an important role in the pathogenesis of preeclampsia and provide a mechanistic link to future disease. In this article, we will discuss the pathophysiology of preeclampsia, the many mechanisms of cellular senescence, evidence for the involvement of senescence in the development of preeclampsia, as well as evidence that cellular senescence may link preeclampsia to the risk of future disease. Lastly, we will explore how a better understanding of the role of cellular senescence in preeclampsia may lead to therapeutic trials. © 2023 American Physiological Society. Compr Physiol 13:5077-5114, 2023.

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衰老和细胞衰老对子痫前期病理生理学的影响。

妊娠期高血压疾病的发病率正在增加，这可能是由于几个因素造成的，包括妊娠期年龄的增加和生育期更多的合并健康状况。先兆子痫是妊娠期最严重的高血压疾病，与未来疾病（包括心血管和肾脏疾病）的风险增加有关。细胞衰老是细胞周期因许多生理和不适应刺激而停滞的过程，可能在先兆子痫的发病机制中发挥重要作用，并为未来的疾病提供机制联系。在这篇文章中，我们将讨论先兆子痫的病理生理学、细胞衰老的许多机制、衰老参与先兆子痫发展的证据，以及细胞衰老可能将先兆子痫与未来疾病风险联系起来的证据。最后，我们将探讨如何更好地理解细胞衰老在先兆子痫中的作用，从而进行治疗试验。©2023美国生理学会。Compr Physiol 13:5077-5112023。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Comprehensive Physiology PHYSIOLOGY-

CiteScore

10.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information ever assembled, and uses the most powerful features of review journals and electronic reference works to cover the latest key developments in the field, through the most authoritative articles on the subjects covered. This makes Comprehensive Physiology a valued reference work on the evolving science of physiology for both researchers and clinicians. It also provides a useful teaching tool for instructors and an informative resource for medical students and other students in the life and health sciences.