Trends and Disparities in Stage-Specific Incidence of Hepatocellular Carcinoma among US Adults, 2004-2019.

IF 11.6 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Liver Cancer Pub Date : 2022-12-05 eCollection Date: 2023-08-01 DOI:10.1159/000528374

Haoting Shi, Jingxuan Huang, Shi Zhao, Yiwen Jin, Rong Cai, Jinjun Ran

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引用次数: 1

Abstract

Introduction: The aim of this study was to determine the stage-specific incidence trend of hepatocellular carcinoma (HCC) among US adults.

Methods: The age-adjusted incidence rate was extracted from Surveillance, Epidemiology, and End Results database for localized, regional, and distant HCC. Trend analyses were conducted in the overall population and stratified by demographic and sociodemographic variables. The annual percentage change (APC) in 2014-2019 was estimated to determine the stage-specific incidence trend.

Results: Although the incidence of localized HCC significantly declined, the incidence for regional and distant HCC plateaued in 2014-2019 (APCs, 4.4% [95% CI, -0.2% to 9.3%] and -0.7% [95% CI, -1.8% to 0.5%], respectively) with age and race/ethnicity disparities. More pronounced increases for regional and distant HCC were observed among the elderly (APCs, 8.4% [95% CI, 4.8-12.2%] and 2.2% [95% CI, 1.7-2.7%] for regional and distant HCC, respectively), non-Hispanic white individuals (APCs, 4.0% [95% CI, 2.9-5.1%] and 1.5% [95% CI, 0.7-2.4%] for regional and distant HCC, respectively).

Conclusions: Disparities in incidence trends may reflect the inequalities in access to primary health care. More efforts are still in great demand for the vulnerable population.

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2004-2019年美国成年人肝细胞癌分期特异性发病率的趋势和差异。

引言：本研究的目的是确定美国成年人肝细胞癌（HCC）的分期特异性发病趋势。方法：从局部、区域和远处HCC的监测、流行病学和最终结果数据库中提取年龄调整后的发病率。趋势分析是在总体人口中进行的，并根据人口和社会人口变量进行分层。估计2014-2019年的年度百分比变化（APC），以确定特定阶段的发病趋势。结果：尽管局限性HCC的发病率显著下降，但由于年龄和种族/民族差异，2014-2019年区域和远处HCC的发生率趋于平稳（APC，分别为4.4%[95%CI，-0.2%-9.3%]和-0.7%[95%CI、-1.8%-0.5%]）。在老年人中观察到区域性和远处HCC的增加更为明显（区域性和远距离HCC的APC分别为8.4%[95%CI，4.8-12.2%]和2.2%[95%CI，1.7-2.7%]），非西班牙裔白人个体（区域和远处HCC的APC分别为4.0%[95%CI，2.9-5.1%]和1.5%[95%CI，0.7-2.4%]）。结论：发病率趋势的差异可能反映了获得初级卫生保健的不平等。弱势群体仍然需要作出更多努力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Liver Cancer Medicine-Oncology

CiteScore

20.80

自引率

7.20%

发文量

审稿时长

16 weeks

期刊介绍： Liver Cancer is a journal that serves the international community of researchers and clinicians by providing a platform for research results related to the causes, mechanisms, and therapy of liver cancer. It focuses on molecular carcinogenesis, prevention, surveillance, diagnosis, and treatment, including molecular targeted therapy. The journal publishes clinical and translational research in the field of liver cancer in both humans and experimental models. It publishes original and review articles and has an Impact Factor of 13.8. The journal is indexed and abstracted in various platforms including PubMed, PubMed Central, Web of Science, Science Citation Index, Science Citation Index Expanded, Google Scholar, DOAJ, Chemical Abstracts Service, Scopus, Embase, Pathway Studio, and WorldCat.