Characteristics of deceleration capacity and deceleration runs in vasovagal syncope.

IF 3.9 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Autonomic Research Pub Date : 2024-02-01 Epub Date: 2023-09-30 DOI:10.1007/s10286-023-00989-z

Jiakun Li, Wei Sun, Xu Yang, Bin Tu, Simin Cai, Feng Hu, Zhiyuan Weng, Shangyu Liu, Zihao Lai, Lihui Zheng, Yan Yao

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引用次数: 0

Abstract

Purpose: Increased vagal activity plays a prominent role in vasovagal syncope (VVS). The aim of this study was to characterize vagal function in VVS by evaluating the heart rate (HR) deceleration capacity (DC) and the HR deceleration runs (DRs) in patients with VVS between attacks.

Methods: A total of 188 consecutive VVS patients were enrolled in the study, of whom 129 had positive head-up tilt test (HUTT); 132 healthy participants were enrolled as controls. DC, DRs (DR2, i.e., episodes of 2 consecutive beat-to-beat HR decelerations), and the sum of DR8-10 (very long DR [VLDR]) were calculated using 24-h electrograms. Clinical characteristics, DC, and DRs were compared among syncope groups and controls.

Results: Patients with VVS had higher DC (10.63 ± 2.1 vs. 6.58 ± 1.7 ms; P < 0.001) and lower minimum HR and DR6-10 than controls. No significant differences in DC or DR6-10 were found between the patients with positive and those with negative HUTT results. In multivariate logistic regression analysis, minimum HR ≥ 40 bpm (odds ratio [OR] 0.408, 95% confidence interval [CI] 0.167-0.989; P = 0.048), daytime DC ≥ 7.37 ms (OR 3.040, 95% CI 1.220-7.576; P = 0.013), and VLDR ≥ 0.046% (OR 0.306, 95% CI 0.138-0.679; P = 0.004) were demonstrated to be risk factors significantly associated with VVS.

Conclusion: Compared to healthy controls, patients with VVS demonstrated distinct HR deceleration profiles between attacks, including overall higher DC and lower DR6-10.

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血管迷走性晕厥减速能力和减速跑的特点。

目的：迷走神经活动增加在血管迷走性晕厥（VVS）中起重要作用。本研究的目的是通过评估VVS患者发作之间的心率（HR）减速能力（DC）和HR减速行程（DR）来表征VVS患者的迷走神经功能。方法：共有188名连续的VVS患者参与研究，其中129人的抬头倾斜试验（HUTT）呈阳性；132名健康参与者被纳入对照组。使用24小时电描记图计算DC、DR（DR2，即2次连续心跳到心跳HR减速的发作）和DR8-10（超长DR[VLDR]）的总和。比较晕厥组和对照组的临床特征、DC和DR。结果：VVS患者的DC较高（10.63 ± 2.1对6.58 ± 1.7毫秒；P 结论：与健康对照组相比，VVS患者在发作之间表现出明显的HR减速特征，包括总体较高的DC和较低的DR6-10。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Autonomic Research 医学-临床神经学

CiteScore

7.40

自引率

6.90%

发文量

审稿时长

>12 weeks

期刊介绍： Clinical Autonomic Research aims to draw together and disseminate research work from various disciplines and specialties dealing with clinical problems resulting from autonomic dysfunction. Areas to be covered include: cardiovascular system, neurology, diabetes, endocrinology, urology, pain disorders, ophthalmology, gastroenterology, toxicology and clinical pharmacology, skin infectious diseases, renal disease. This journal is an essential source of new information for everyone working in areas involving the autonomic nervous system. A major feature of Clinical Autonomic Research is its speed of publication coupled with the highest refereeing standards.