Nrf2 and Ferroptosis: A New Research Direction for Ischemic Stroke.

IF 3.6 4区 医学 Q3 CELL BIOLOGY
Cellular and Molecular Neurobiology Pub Date : 2023-11-01 Epub Date: 2023-09-20 DOI:10.1007/s10571-023-01411-y
Xiaoman Deng, Wenming Chu, Hanrui Zhang, Yongjun Peng
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引用次数: 0

Abstract

Ischemic stroke (IS) is one of the leading causes of death and morbidity worldwide. As a novel form of cell death, ferroptosis is an important mechanism of ischemic stroke. Nuclear factor E2-related factor 2 (Nrf2) is the primary regulator of cellular antioxidant response. In addition to alleviating ischemic stroke nerve damage by reducing oxidative stress, Nrf2 regulates genes associated with ferroptosis, suggesting that Nrf2 may inhibit ferroptosis after ischemic stroke. However, the specific pathway of Nrf2 on ferroptosis in the field of ischemic stroke remains unclear. Therefore, this paper provides a concise overview of the mechanisms underlying ferroptosis, with a particular focus on the regulatory role of Nrf2. The discussion highlights the potential connections between Nrf2 and the mitigation of oxidative stress, regulation of iron metabolism, modulation of the interplay between ferroptosis and inflammation, as well as apoptosis. This paper focuses on the specific pathway of Nrf2 regulation of ferroptosis after ischemic stroke, providing scientific research ideas for further research on the treatment of ischemic stroke.

Abstract Image

Nrf2与铁下垂:缺血性脑卒中的新研究方向。
缺血性中风(IS)是世界范围内死亡和发病的主要原因之一。脱铁性贫血作为一种新的细胞死亡形式,是缺血性脑卒中的重要机制。核因子E2相关因子2(Nrf2)是细胞抗氧化反应的主要调节因子。除了通过减少氧化应激来减轻缺血性中风神经损伤外,Nrf2还调节与脱铁症相关的基因,这表明Nrf2可能抑制缺血性中风后的脱铁症。然而,Nrf2在缺血性中风领域中的铁蛋白脱失的具体途径尚不清楚。因此,本文简要概述了脱铁性贫血的潜在机制,特别关注Nrf2的调节作用。该讨论强调了Nrf2与减轻氧化应激、调节铁代谢、调节脱铁症和炎症之间的相互作用以及细胞凋亡之间的潜在联系。本文重点研究了Nrf2调节缺血性脑卒中后脱铁性贫血的具体途径,为进一步研究缺血性脑卒中的治疗提供了科学的研究思路。
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来源期刊
CiteScore
7.70
自引率
0.00%
发文量
137
审稿时长
4-8 weeks
期刊介绍: Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.
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