The emerging role of the hedgehog signaling pathway in immunity response and autoimmune diseases.

IF 3.3 4区 医学 Q3 IMMUNOLOGY
Autoimmunity Pub Date : 2023-12-01 Epub Date: 2023-09-23 DOI:10.1080/08916934.2023.2259127
Yunfei Li, Min Ming, Chunyang Li, Songpo Liu, Dan Zhang, Tao Song, Jun Tan, Jidong Zhang
{"title":"The emerging role of the hedgehog signaling pathway in immunity response and autoimmune diseases.","authors":"Yunfei Li,&nbsp;Min Ming,&nbsp;Chunyang Li,&nbsp;Songpo Liu,&nbsp;Dan Zhang,&nbsp;Tao Song,&nbsp;Jun Tan,&nbsp;Jidong Zhang","doi":"10.1080/08916934.2023.2259127","DOIUrl":null,"url":null,"abstract":"<p><p>The Hedgehog (Hh) family is a prototypical morphogen involved in embryonic patterning, multi-lineage differentiation, self-renewal, morphogenesis, and regeneration. There are studies that have demonstrated that the Hh signaling pathway differentiates developing T cells into MHC-restricted self-antigen tolerant T cells in a concentration-dependent manner in the thymus. Whereas Hh signaling pathway is not required in the differentiation of B cells but is indispensable in maintaining the regeneration of hematopoietic stem cells (HSCs) and the viability of germinal centers (GCs) B cells. The Hh signaling pathway exerts both positive and negative effects on immune responses, which involves activating human peripheral CD4<sup>+</sup> T cells, regulating the accumulation of natural killer T (NKT) cells, recruiting and activating macrophages, increasing CD4<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells in the inflammation sites to sustain homeostasis. Hedgehog signaling is involved in the patterning of the embryo, as well as homeostasis of adult tissues. Therefore, this review aims to highlight evidence for Hh signaling in the differentiation, function of immune cells and autoimmune disease. Targeting Hh signaling promises to be a novel, alternative or adjunct approach to treating tumors and autoimmune diseases.</p>","PeriodicalId":8688,"journal":{"name":"Autoimmunity","volume":"56 1","pages":"2259127"},"PeriodicalIF":3.3000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Autoimmunity","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/08916934.2023.2259127","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/9/23 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

The Hedgehog (Hh) family is a prototypical morphogen involved in embryonic patterning, multi-lineage differentiation, self-renewal, morphogenesis, and regeneration. There are studies that have demonstrated that the Hh signaling pathway differentiates developing T cells into MHC-restricted self-antigen tolerant T cells in a concentration-dependent manner in the thymus. Whereas Hh signaling pathway is not required in the differentiation of B cells but is indispensable in maintaining the regeneration of hematopoietic stem cells (HSCs) and the viability of germinal centers (GCs) B cells. The Hh signaling pathway exerts both positive and negative effects on immune responses, which involves activating human peripheral CD4+ T cells, regulating the accumulation of natural killer T (NKT) cells, recruiting and activating macrophages, increasing CD4+Foxp3+ regulatory T cells in the inflammation sites to sustain homeostasis. Hedgehog signaling is involved in the patterning of the embryo, as well as homeostasis of adult tissues. Therefore, this review aims to highlight evidence for Hh signaling in the differentiation, function of immune cells and autoimmune disease. Targeting Hh signaling promises to be a novel, alternative or adjunct approach to treating tumors and autoimmune diseases.

刺猬信号通路在免疫反应和自身免疫性疾病中的新作用。
Hedgehog(Hh)家族是一种典型的形态发生素,参与胚胎模式、多谱系分化、自我更新、形态发生和再生。有研究表明,Hh信号通路在胸腺中以浓度依赖的方式将发育中的T细胞分化为MHC限制性自身抗原耐受性T细胞。而Hh信号通路在B细胞分化中不是必需的,但在维持造血干细胞(HSC)的再生和生发中心(GC)B细胞的活力中是必不可少的。Hh信号通路对免疫反应既有积极作用,也有消极作用,包括激活人外周CD4+T细胞,调节自然杀伤T(NKT)细胞的积累,募集和激活巨噬细胞,增加炎症部位的CD4+Foxp3+调节性T细胞以维持体内平衡。Hedgehog信号传导参与胚胎的模式以及成年组织的稳态。因此,本综述旨在强调Hh信号在免疫细胞分化、功能和自身免疫性疾病中的作用。靶向Hh信号有望成为治疗肿瘤和自身免疫性疾病的一种新的、替代的或辅助的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Autoimmunity
Autoimmunity 医学-免疫学
CiteScore
5.70
自引率
8.60%
发文量
59
审稿时长
6-12 weeks
期刊介绍: Autoimmunity is an international, peer reviewed journal that publishes articles on cell and molecular immunology, immunogenetics, molecular biology and autoimmunity. Current understanding of immunity and autoimmunity is being furthered by the progress in new molecular sciences that has recently been little short of spectacular. In addition to the basic elements and mechanisms of the immune system, Autoimmunity is interested in the cellular and molecular processes associated with systemic lupus erythematosus, rheumatoid arthritis, Sjogren syndrome, type I diabetes, multiple sclerosis and other systemic and organ-specific autoimmune disorders. The journal reflects the immunology areas where scientific progress is most rapid. It is a valuable tool to basic and translational researchers in cell biology, genetics and molecular biology of immunity and autoimmunity.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信