A solid preparation of phytochemicals: improvement of the solubility and bioavailability of astragaloside IV based on β-cyclodextrin microencapsulation

IF 2.1 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Chemical Papers Pub Date : 2023-07-24 DOI:10.1007/s11696-023-02953-7

Yao Wang, Xu Han, Xiang-Yu Qin, Ying Zhang, Na Guo, Han-Lin Zhu, Yu-Jie Fu

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Abstract

Astragaloside IV/β-cyclodextrin inclusion complex (AsIV/β-CD IC) was successfully prepared by low-temperature sedimentation technology. Under the preparation conditions inclusion temperature 60 °C, inclusion time 3 h, core–wall material molar ratio 1:1, and inclusion rate 750 rpm, the optimal encapsulation efficiency reached 81.63%. It was characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometer (XRD) and thermogravimetric (TGA). Physicochemical characterization of the AsIV/β-CD IC indicated that the complexation of AsIV/β-CD was successful, and the thermal stability of AsIV was improved clearly. Through granulation technology, astragalus saponin granules (ASG) with uniform size from AsIV/β-CD IC were obtained. ASG possessed significant water solubility and storage stability beside fine taste. In addition, ASG demonstrated beneficial bioactivity in antioxidant and antibacterial functions. Antioxidative stress detection showed that ASG could inhibit the increase of malondialdehyde (MDA) content and the decrease of superoxide dismutase (SOD) content in cells caused by lipopolysaccharides (LPS). In addition, in vitro antibacterial experiments of ASG showed that ASG has obvious antibacterial activity against 6 strains, especially the minimum inhibitory concentration (MIC) value of Escherichia coli and Bacillus subtilis reached 12.5 mg/mL.

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植物化学物质的固体制剂：基于β-环糊精微胶囊化提高黄芪甲苷IV的溶解度和生物利用度

采用低温沉淀技术成功制备了黄芪甲苷IV/β-环糊精包合物（AsIV/β-CD-IC）。在包埋温度60°C、包埋时间3h、核壁材料摩尔比1:1、包埋速度750rpm的制备条件下，最佳包埋效率达到81.63%。通过扫描电子显微镜（SEM）、傅立叶变换红外光谱（FTIR）、X射线衍射仪（XRD）和热重分析（TGA）对其进行了表征。AsIV/β-CD IC的理化性质表明，AsIV/α-CD的络合反应是成功的，AsIV的热稳定性明显提高。通过制粒工艺，从AsIV/β-CD-IC中制备出大小均匀的黄芪皂苷颗粒。ASG具有显著的水溶性和储存稳定性，口感细腻。此外，ASG在抗氧化和抗菌功能方面表现出有益的生物活性。抗氧化应激检测表明，ASG能抑制脂多糖（LPS）引起的细胞丙二醛（MDA）含量的增加和超氧化物歧化酶（SOD）含量的降低。此外，ASG的体外抗菌实验表明，ASG对6株菌株具有明显的抗菌活性，尤其是对大肠杆菌和枯草芽孢杆菌的最低抑菌浓度（MIC）值达到12.5mg/mL

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来源期刊

Chemical Papers 化学-化学综合

CiteScore

3.90

自引率

4.50%

发文量

590

审稿时长

2.5 months

期刊介绍： Chemical Papers is a peer-reviewed, international journal devoted to basic and applied chemical research. It has a broad scope covering the chemical sciences, but favors interdisciplinary research and studies that bring chemistry together with other disciplines.