Analysis of the effect of ageing on rising edge characteristics of the photoplethysmogram using a modified Windkessel model.

Edmond Zahedi, Kalaivani Chellappan, Mohd Alauddin Mohd Ali, Harwant Singh
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引用次数: 57

Abstract

Ageing is one of the main contributing factors towards increasing arterial stiffness, leading to changes in peripheral pulses propagation. Therefore the characteristics of the photoplethysmogram (PPG) pulse, especially the rising edge and peak position, are greatly affected. In this study, the PPG pulse rising edge and corresponding peak position have been investigated non-invasively in human subjects as a function of age. Fifteen healthy subjects were selected and grouped in five age intervals, from 20 to 59 years, based on their comparable systolic-diastolic blood pressure and PPG amplitude. As expected, the peripheral pulse shows a steep rise and early peak in younger subjects. With age, the slope becomes blunted and in older subjects, the rise is very gradual and the pulse peak appears much later. Qualitative results were further verified by a modified 10-element Windkessel model to quantify the lumped parameter changes with ageing. This verification highlighted some specific changes in vascular parameters with aging. The rising edge could be considered as one parameter in determining the age-dependent vascular state.

用改进的Windkessel模型分析老化对光容积曲线上升沿特性的影响。
老化是动脉硬化增加的主要因素之一,导致外周脉冲传播的变化。因此,光容积脉搏图(PPG)脉冲的特性,特别是上升沿和峰值位置受到很大影响。在这项研究中,我们对人类受试者的PPG脉冲上升沿和相应的峰值位置作为年龄的函数进行了无创研究。选取15名健康受试者,根据其可比较的收缩压-舒张压和PPG振幅,将其分为5个年龄区间,从20岁到59岁。不出所料,年轻受试者的外周脉搏呈急剧上升和早期峰值。随着年龄的增长,斜率变钝,在老年受试者中,上升非常缓慢,脉冲峰值出现的时间也要晚得多。通过改进的10元Windkessel模型进一步验证了定性结果,量化了总参数随老化的变化。这一验证强调了随着年龄增长血管参数的一些特定变化。血管上升沿可以作为判断血管随年龄变化状态的一个参数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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