An electrochemical sensor for determination of calcium dobesilate based on PoPD/MWNTs composite film modified glassy carbon electrode

Journal of biochemical and biophysical methods Pub Date : 2008-04-24 DOI:10.1016/j.jbbm.2007.10.002

Xiuhua Zhang, Shimin Wang, Li Jia, Zuxun Xu, Yu Zeng

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引用次数: 21

Abstract

A poly-o-phenylenediamine and multi-wall carbon nanotubes composite (PoPD/MWNTs) modified glassy carbon electrode (GCE) was prepared by in situ electropolymerization using an ionic surfactant as the supporting electrolyte. The morphology of the resulting PoPD/MWNTs composite was characterized by TEM and the electrochemical properties of the modified electrode were characterized by cyclic voltammetry. The electrochemical behavior of calcium dobesilate on PoPD/MWNTs modified electrode was also investigated. The large current response of calcium dobesilate on PoPD/MWNTs modified electrode is probably caused by the synergistic effect of the electrocatalytic property of PoPD and MWNTs. The reductive peak current increased linearly with the concentration of calcium dobesilate in the range of 0.1–1.0 μmol/L and 4.0–400 μmol/L by square wave adsorptive stripping voltammetry, respectively. The detection limit (three times the signal blank/slope) was 0.035 μmol/L. The modified electrode could eliminate the interference of dopamine, norepinephrine and epinephrine at 100-, 90- and 70-fold concentration of 1.0 μmol/L calcium dobesilate, respectively. The proposed modified electrode provides a new promising and alternative way to detect calcium dobesilate.

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基于PoPD/MWNTs复合膜修饰玻碳电极的多苯磺酸钙电化学传感器的研究

以离子表面活性剂为支撑电解质，采用原位电聚合法制备了聚邻苯二胺-多壁碳纳米管复合材料(PoPD/MWNTs)修饰的玻碳电极(GCE)。用TEM表征了复合材料的形貌，并用循环伏安法表征了改性电极的电化学性能。研究了聚苯磺酸钙在PoPD/MWNTs修饰电极上的电化学行为。聚苯磺酸钙在PoPD/MWNTs修饰电极上的大电流响应可能是由于PoPD和MWNTs的电催化性能协同作用所致。方波吸附溶出伏安法测定还原峰电流在0.1 ~ 1.0 μmol/L和4.0 ~ 400 μmol/L范围内随多苯磺酸钙浓度的增加呈线性增加;检测限(3倍于信号空白/斜率)为0.035 μmol/L。在1.0 μmol/L多苯磺酸钙浓度为100倍、90倍和70倍时，电极可以消除多巴胺、去甲肾上腺素和肾上腺素的干扰。所提出的修饰电极为检测多苯磺酸钙提供了一种新的、有前途的替代方法。

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Journal of biochemical and biophysical methods

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