L Pollak, Y Dobronevsky, T Prohorov, S Bahunker, J M Rabey
{"title":"Low dose methylphenidate improves freezing in advanced Parkinson's disease during off-state.","authors":"L Pollak, Y Dobronevsky, T Prohorov, S Bahunker, J M Rabey","doi":"10.1007/978-3-211-73574-9_17","DOIUrl":null,"url":null,"abstract":"<p><p>Five men with advanced idiopathic Parkinson's disease (PD) were examined to assess the effect of low dose methylphenidate (MPD) on gait. The patients were tested during \"off\" state before and two hours after the intake of 10 mg MPD while walking an \"8 trajectory\". The total walking time, total freezing time, number of freezing episodes and the non-freezing walking time were assessed. The obtained data were compared by the Wilcoxon Signed Rank test with a type I error rate of 0.05. The results showed a statistically significant improvement in all gait parameters after MPD intake. Moreover, a good correlation in the grade of improvement for each individual gait characteristic was found. The study demonstrates that low dose of MPD may improve gait, and especially freezing, in patients with severe PD, without the need for exogenous L-dopa. The mechanism of MPD action in patients with advanced PD is further discussed.</p>","PeriodicalId":16395,"journal":{"name":"Journal of Neural Transmission-supplement","volume":" 72","pages":"145-8"},"PeriodicalIF":0.0000,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"49","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neural Transmission-supplement","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/978-3-211-73574-9_17","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 49
Abstract
Five men with advanced idiopathic Parkinson's disease (PD) were examined to assess the effect of low dose methylphenidate (MPD) on gait. The patients were tested during "off" state before and two hours after the intake of 10 mg MPD while walking an "8 trajectory". The total walking time, total freezing time, number of freezing episodes and the non-freezing walking time were assessed. The obtained data were compared by the Wilcoxon Signed Rank test with a type I error rate of 0.05. The results showed a statistically significant improvement in all gait parameters after MPD intake. Moreover, a good correlation in the grade of improvement for each individual gait characteristic was found. The study demonstrates that low dose of MPD may improve gait, and especially freezing, in patients with severe PD, without the need for exogenous L-dopa. The mechanism of MPD action in patients with advanced PD is further discussed.
对5名晚期特发性帕金森病(PD)患者进行了检查，以评估低剂量哌甲酯(MPD)对步态的影响。患者在服用10 mg MPD前和服用后2小时处于“关闭”状态，并以“8轨迹”行走。评估总步行时间、总冻结时间、冻结次数和非冻结步行时间。所得数据采用Wilcoxon Signed Rank检验进行比较，I型错误率为0.05。结果显示，服用MPD后，所有步态参数都有统计学上的显著改善。此外，发现每个个体步态特征的改善程度具有良好的相关性。该研究表明，低剂量的MPD可以改善严重PD患者的步态，特别是冻结，而不需要外源性左旋多巴。进一步探讨了MPD在晚期PD患者中的作用机制。
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
