Original Synthesis of Enyne Dicarboxylic Acids

IF 0.8 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Doklady Chemistry Pub Date : 2022-11-02 DOI:10.1134/S0012500822600079

S. A. Sokov, S. S. Zlotsky, A. V. Vologzhanina, A. A. Golovanov

引用次数: 0

Abstract

The condensation of arylpropargyl aldehydes with malonic acid in AcOH has led to the formation of 2-(3-arylprop-2-yn-1-ylidene)malonic acids in 68–85% yields. A similar reaction with 4-fluorophenylpropargyl aldehyde in ethanol in the presence of 2-aminopyridine has resulted in intramolecular cyclization to give previously unknown 5-(4-fluorobenzylidene)-2-oxo-2,5-dihydrofuran-3-carboxylate. The structure of this compound has been studied in detail by X-ray diffraction.

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炔二羧酸的原始合成

芳基丙基醛与丙二酸在AcOH中缩合生成2-(3-芳基丙-2-炔-1-基二烯)丙二酸，产率为68-85%。在2-氨基吡啶的存在下，在乙醇中与4-氟苯丙炔醛发生了类似的反应，导致分子内环化，得到以前未知的5-(4-氟苄基)-2-氧-2,5-二氢呋喃-3-羧酸盐。这种化合物的结构已用x射线衍射法进行了详细的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Doklady Chemistry 化学-化学综合

CiteScore

1.20

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Doklady Chemistry is a journal that publishes new research in chemistry and chemical engineering of great significance. Initially the journal was a forum of the Russian Academy of Science and published only best contributions from Russia in the form of short articles. Now the journal welcomes submissions from any country in the English or Russian language. Every manuscript must be recommended by Russian or foreign members of the Russian Academy of Sciences.