Pharmacological Properties of BN82451: A Novel Multitargeting Neuroprotective Agent

Pierre Etienne Chabrier, Michel Auguet
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引用次数: 17

Abstract

BN82451 belongs to a new family of small molecules designated as multitargeting or hybrid molecules. BN82451 is orally active, has good central nervous system penetration, and elicits potent neuronal protection and antiinflammatory properties. Neuronal protection is due to Na+ channel blockade, antioxidant properties, and mitochondria-protecting activity, whereas inhibition of cyclooxygenases is mostly responsible for its antiinflammatory activity. BN82451 has been shown to exert a potent neuroprotective effect in various in vitro and in vivo animal models. BN82451 was found to exert a significant protection in experimental animal models mimicking aspects of cerebral ischemia, Parkinson disease, Huntington disease, and more particularly amyotrophic lateral sclerosis. Collectively, its pharmacological properties designate BN82451 as a promising neuroprotective agent.

Abstract Image

新型多靶点神经保护剂BN82451的药理特性
BN82451属于一个新的小分子家族,被称为多靶向或杂交分子。BN82451具有口服活性,对中枢神经系统有良好的渗透作用,并具有有效的神经元保护和抗炎特性。神经元保护是由于Na+通道阻断、抗氧化特性和线粒体保护活性,而环氧化酶的抑制主要负责其抗炎活性。BN82451已在各种体外和体内动物模型中显示出强大的神经保护作用。BN82451在模拟脑缺血、帕金森病、亨廷顿病,尤其是肌萎缩侧索硬化症的实验动物模型中发挥了显著的保护作用。综上所述,其药理特性表明BN82451是一种很有前途的神经保护剂。
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