A comparative study of the influence of smoking on skin flap survival in pregnant rats

Zekeriya Tosun , Uldis Bite
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引用次数: 8

Abstract

In this study, the effects of smoking on skin flap survival were evaluated. For purposes of comparison 12 female rats were divided into four groups.

Group 1 comprised nonsmoker, nonpregnant rats; group 2 nonsmoker, pregnant rats; group 3 smoker, nonpregnant rats and group 4 smoker pregnant. On each subject a standard 4×10 cm McFarlane dorsal skin flap was raised.

On the seventh day postoperatively, the flaps were traced on a transparent sheet marking off the necrotic areas. The area of skin flap necrosis was assessed by ‘netcad’ digital imaging analysis program.

The area of skin flap viability in the pregnant groups was greater than in the nonpregnant groups. The nonsmoker pregnant group's flap viability was the highest and the smoker nonpregnant group's viability was the lowest.

This result supports the conclusion that pregnancy enhances flap viability and produces some defensive factors against some of the adverse effects of smoking.

吸烟对妊娠大鼠皮瓣存活影响的比较研究
本研究评估吸烟对皮瓣存活的影响。为了比较,将12只雌性大鼠分为四组。第一组包括不吸烟、未怀孕的大鼠;第二组不吸烟的怀孕大鼠;第三组吸烟,未怀孕大鼠,第四组吸烟,怀孕大鼠。在每名受试者上取出一个标准的4×10厘米麦克法兰背侧皮瓣。术后第7天,皮瓣在透明薄片上画出坏死区域。应用“netcad”数字成像分析程序评估皮瓣坏死面积。妊娠组皮瓣存活面积大于非妊娠组。非吸烟孕妇组皮瓣活力最高,吸烟非怀孕组皮瓣活力最低。这一结果支持了妊娠增强皮瓣活力的结论,并对吸烟的一些不利影响产生了一些防御因子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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