Strategic directions in tissue engineering.

Peter C Johnson, Antonios G Mikos, John P Fisher, John A Jansen
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引用次数: 141

Abstract

The field of tissue engineering is developing rapidly. Given its ultimate importance to clinical care, the time is appropriate to assess the field's strategic directions to optimize research and development activities. To characterize strategic directions in tissue engineering, a distant but reachable clinical goal was proposed and a worldwide body of 24 leaders in tissue engineering was queried systematically to determine the best paths toward that goal. Using a modified Hoshin process, we identified 14 critical activity categories and then stratified them by their immediate priority for the field. The result of the analysis illustrates a highly interdependent set of activities that are dominated by the need for an understanding of angiogenesis, stem cell science, and the utilization of molecular biology and systems biology tools to enable a deeper comprehension of tissue development and control.

组织工程的战略方向。
组织工程领域正在迅速发展。鉴于其对临床护理的最终重要性,现在是评估该领域的战略方向以优化研究和开发活动的合适时机。为了确定组织工程的战略方向,提出了一个遥远但可实现的临床目标,并系统地询问了组织工程领域24位领导者的全球机构,以确定实现该目标的最佳途径。使用改进的Hoshin流程,我们确定了14个关键活动类别,然后根据它们在该领域的直接优先级对它们进行分层。分析结果说明了一组高度相互依赖的活动,这些活动主要是对血管生成、干细胞科学的理解,以及对分子生物学和系统生物学工具的利用,以加深对组织发育和控制的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Tissue engineering
Tissue engineering CELL & TISSUE ENGINEERING-BIOTECHNOLOGY & APPLIED MICROBIOLOGY
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