ESTERIFICATION OF CHOLESTEROL BY CANINE ADRENAL CELL FRACTIONS.

Abstract

Summary Canine adrenal cell fraction (mitochondria, microsomes, and soluble fraction) were found to convert cholesterol-4-C14 to esters and adrenal steroids. The most active cell fraction was mitochondria; mitochondria also contained most of the adrenal cholesterol (as ester). The cholesterol esters synthesized by mitochondria and microsomes contained a high proportion of polyunsaturated fatty acids. The esters synthesized were similar in composition to those present in mitochondria and microsomes.