SOME CYTOLOGIC CHANGES OF RAT LIVER IN EXPERIMENTAL PORPHYRIA.

Abstract

Summary The treatment of rats with allylisopropylacetamide resulted in a doubling of liver size within 3 days. Microscopic examination showed an increase in cell size and less increase in cell number per liver. By chemical analyses, there were found net gains in RNA and DNA per liver which paralleled the size and number of cells respectively. In per cent composition, lipids doubled while other components examined remained unchanged. It was concluded that the cytologic effect of the drug may be 2-fold, resulting primarily in cellular hypertrophy, but also in cellular hyperplasia.