{"title":"EVIDENCE FOR THE PRESENCE OF STEM CELLS IN THE TAIL OF THE MOUSE.","authors":"C V ROBINSON, S L COMMERFORD, J L BATEMAN","doi":"10.3181/00379727-119-30142","DOIUrl":null,"url":null,"abstract":"Summary In experiments in which the tails of mice were shielded during exposure to X-rays, colonization of the spleen occurred in excess of that found in whole-body irradiated control animals. This was the case whether the measure of effect was post-irradiative gain in spleen weight, uptake of IDU (5-iodo-2′-deoxyuridine), or nodule count. The degree of colonization was found to be a function of the length of time which elapsed between the original irradiation (with tail shielded) and a subsequent, suppressive irradiation of the tail. Histological examination showed that the spleen nodules were hemopoietic, and that normal tail vertebrae contained hemopoietic tissue.","PeriodicalId":20675,"journal":{"name":"Proceedings of the Society for Experimental Biology and Medicine","volume":" ","pages":"222-6"},"PeriodicalIF":0.0000,"publicationDate":"1965-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3181/00379727-119-30142","citationCount":"23","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Society for Experimental Biology and Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3181/00379727-119-30142","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 23
Abstract
Summary In experiments in which the tails of mice were shielded during exposure to X-rays, colonization of the spleen occurred in excess of that found in whole-body irradiated control animals. This was the case whether the measure of effect was post-irradiative gain in spleen weight, uptake of IDU (5-iodo-2′-deoxyuridine), or nodule count. The degree of colonization was found to be a function of the length of time which elapsed between the original irradiation (with tail shielded) and a subsequent, suppressive irradiation of the tail. Histological examination showed that the spleen nodules were hemopoietic, and that normal tail vertebrae contained hemopoietic tissue.