PREVENTION OF TUBERCULOSIS AND REVERSAL OF TUBERCULIN REACTION IN GUINEA PIGS.

Abstract

Summary Reversal of the tuberculin reaction occurred in 70% of animals treated with INH following development of a positive test. One year of INH treatment failed to sterilize the tissues in 15% of the animals. Evidence is presented that INH completely protected guinea pigs from tuberculosis when treatment was initiated prior to inoculation of a minimal dose. All non-treated controls developed visceral tuberculosis.