ISOSORBIDE, A NEW ORAL OSMOTIC DIURETIC.

Abstract

Summary Isosorbide has been shown to be an effective diuretic when given orally to rats. The urinary output is related to dosage with an 8- or 9-fold increase for the period of 4 hours following a dose of 10 g/kg of body weight. Based on carbon-14 studies, more than 95% of the administered dose is readily excreted largely unchanged in the urine. Because of its effectiveness and very low order of acute and sub-acute toxicity, isosorbide is considered as an orally effective osmotic diuretic.