[Effect of Chemotherapy Course Delay on the Relapse of Paediatric B-cell Acute Lymphoblastic Leukemia].

Zhongguo shi yan xue ye xue za zhi Pub Date : 2022-08-01 DOI:10.19746/j.cnki.issn.1009-2137.2022.04.010

Lu Cao, Jing Gao, Wei Gao, Hu Liu, Jun Lu, Yi Wang, Hai-Long He, Pei-Fang Xiao, Jie Li, Jian-Qin Li, Shao-Yan Hu

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Abstract

Objective: To investigate the effect of course delay of CCLG-ALL-2008 regimen on the relapse of paediatric B-cell acute lymphoblastic leukemia (B-ALL) patients.

Methods: Paediatric B-ALL patients newly diagnosed and treated with CCLG-ALL-2008 regimen in the Children's Hospital of Soochow University from January 2011 to December 2014 were retrospectively analyzed to clarify the relationship between chemotherapy course delay and relapse, and explore the causes of course delay which led to relapse. Patients were followed up until July 2019.

Results: The correlation between treatment delay (number of weeks) and relapse rate was statistically significant (P=0.034), and hazard ratio indicated that longer than 4 weeks had a significant effect. The effect of positive minimal residual disease (MRD) (1×10^-4≤MRD≤1×10^-2) at the 12th week on the relapse rate was also statistically significant (P=0.041). Among the causes of treatment delay, the effect of myelosuppression on the relapse rate was statistically significant (P=0.01).

Conclusion: Treatment delay exceeding 4 weeks, positive MRD at the 12th week, and myelosuppression are independent prognostic factors for relapse.

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化疗疗程延迟对儿童b细胞急性淋巴细胞白血病复发的影响。

目的:探讨CCLG-ALL-2008方案疗程延迟对儿童b细胞急性淋巴细胞白血病(B-ALL)复发的影响。方法:回顾性分析2011年1月至2014年12月苏州大学儿童医院新诊断并接受CCLG-ALL-2008方案治疗的儿童B-ALL患者，明确化疗疗程延迟与复发的关系，并探讨导致复发的疗程延迟原因。患者随访至2019年7月。结果:治疗延迟(周数)与复发率的相关性有统计学意义(P=0.034)，且风险比提示大于4周者有显著影响。第12周阳性最小残留病(MRD) (1×10-4≤MRD≤1×10-2)对复发率的影响也有统计学意义(P=0.041)。在延迟治疗的原因中，骨髓抑制对复发率的影响有统计学意义(P=0.01)。结论:治疗延迟超过4周，第12周MRD阳性，骨髓抑制是复发的独立预后因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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