CLINICAL CASE OF NON-TYPICAL METASTASIS OF NEUROENDOCRINE LUNG CARCINOMA TO THE VASCULAR MEMBRANE OF THE EYE.

Q3 Medicine
L M Zakhartseva, H E Chytaieva, O V Artemov
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引用次数: 0

Abstract

Background: Metastases in eye structures are rare (1-5% cases at systemic spread of different malignancies, mainly breast and lung cancers). The prognosis is poor. The overall survival usually does not exceed 12 or even 6 months. If metastases are found in the choroid membrane, the probability that the patient has multiple metastatic lesions of other organs increases significantly. Lung neuroendocrine neoplasms are rare (1-2% of all malignancies in adults), but mainly aggressive tumors. They are cha-racterized by "blurred", nonspecific clinical symptoms, the correct diagnosis is delayed seriously, and distant metastases are seen in more than 40% of patients (usually in chest structures, liver, bones, brain, and adrenal glands; metastasis to vascular membrane of the eye ranks the 6th place).

Case report: Own clinical observation of a male patient with rare metastasis of lung neuroendocrine carcinoma to the choroid of the left eye is presented. The disease is manifested by an ocular metastasis, which was initially considered an embryonic tumor. Other metastatic lesions (hilar lymph nodes, liver, soft tissues) were detected on computed tomography a little bit later. The diagnostic algorithm using routine histological examination and immunohistochemistry, including detection of neuroendocrine markers (chromogranin A, synaptophysin), cytokeratin 7 and Ki-67 expression in primary and metastatic tumors is described.

非典型神经内分泌肺癌向眼血管膜转移1例。
背景:眼部结构转移是罕见的(1-5%的病例在不同的恶性肿瘤,主要是乳腺癌和肺癌的全身扩散)。预后很差。总生存期通常不超过12个月甚至6个月。如果在脉络膜内发现转移灶,则患者有其他器官多发转移灶的可能性显著增加。肺神经内分泌肿瘤很少见(占成人所有恶性肿瘤的1-2%),但主要是侵袭性肿瘤。其特点是临床症状“模糊”,非特异性,正确诊断严重延迟,超过40%的患者可见远处转移(通常在胸部结构、肝脏、骨骼、大脑和肾上腺;眼部血管膜转移排在第6位)。病例报告:报告1例罕见的男性肺神经内分泌癌转移至左眼脉络膜的临床观察。该病表现为眼部转移,最初被认为是胚胎肿瘤。其他转移性病变(肺门淋巴结、肝脏、软组织)稍晚在计算机断层扫描上被发现。描述了使用常规组织学检查和免疫组织化学的诊断算法,包括检测原发性和转移性肿瘤中的神经内分泌标志物(嗜铬粒蛋白A、突触素)、细胞角蛋白7和Ki-67的表达。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Experimental oncology
Experimental oncology Medicine-Oncology
CiteScore
1.40
自引率
0.00%
发文量
49
期刊介绍: The Experimental Oncology is an English-language journal that publishes review articles, original contributions, short communications, case reports and technical advances presenting new data in the field of experimental and fundamental oncology. Manuscripts should be written in English, contain original work, which has not been published or submitted for publication elsewhere. It also implies the transfer of the Copyright from the author to “Experimental Oncology”. No part of journal publications may be reproduced, stored in a retrieval system or transmitted in any form or by any means without the prior permission of the publisher.
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