EXPRESSION OF CHEMOKINE (C-C MOTIF) RECEPTOR 7 IN PROSTATE CANCER TISSUE OF YOUNG PATIENTS AND IN METASTATIC CANCER CELLS.

Q3 Medicine

Experimental oncology Pub Date : 2022-08-01 DOI:10.32471/exp-oncology.2312-8852.vol-44-no-2.18025

R Parra-Medina, C Payán-Gómez, N L Acosta-Vega, S Ramírez-Clavijo

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引用次数: 0

Abstract

Background: Chemokine (C-C motif) receptor 7 (CCR7) is a chemokine receptor involved in the carcinogenesis of several types of tumors due to its promoting action in epithelial-mesenchymal transition events, invasion, angiogenesis and metastasis. However, its role in prostate cancer (PCa) remains unclear.

Aim: To evaluate CCR7 expression by immunohistochemistry in prostate tumors from young patients and to determine the possible relationship with the clinicopathological characteristics.

Materials and methods: We analyzed retrospectively paraffin-embedded tissue sections from 23 young PCa (≤ 55 years old) patients and evaluated the transcriptomic expression in the TCGA database.

Results: Expression of CCR7 was observed in 15 cases (65%). The tissue samples from younger patients (≤ 50 years) were mostly positive in 72.7% (8/11) of cases. High grade GS (≥ 3) tumors were CCR7-positive in 71% cases. The malignant cells present in lymph nodes were CCR7 positive in 100% cases. The bioinformatic analysis showed a high CCR7 expression associated with the presence of metastasis (FC = 2.6, p = 0.03) in the Cancer Genome Atlas (TCGA) PCa cohort (PRAD).

Conclusion: We showed that CCR7 expression in tumors from young patients is associated with the early onset of the disease and could also be related to lymph node metastasis.

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趋化因子(c-c motif)受体7在年轻患者前列腺癌组织和转移性癌细胞中的表达

背景:趋化因子(C-C motif)受体7 (CCR7)是一种趋化因子受体，通过促进上皮-间质转化事件、侵袭、血管生成和转移，参与多种肿瘤的癌变。然而，其在前列腺癌(PCa)中的作用尚不清楚。目的:应用免疫组化方法评价年轻前列腺肿瘤患者CCR7的表达，并探讨其与临床病理特征的关系。材料和方法:我们回顾性分析了23例年轻PCa(≤55岁)患者的石蜡包埋组织切片，并在TCGA数据库中评估了转录组表达。结果:CCR7表达15例(65%)。72.7%(8/11)的年轻患者(≤50岁)的组织样本呈阳性。高分级GS(≥3)肿瘤中71%为ccr7阳性。淋巴结内的恶性细胞CCR7 100%呈阳性。生物信息学分析显示，在癌症基因组图谱(TCGA) PCa队列(PRAD)中，CCR7高表达与转移存在相关(FC = 2.6, p = 0.03)。结论:我们发现CCR7在年轻患者肿瘤中的表达与疾病的早期发病有关，也可能与淋巴结转移有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental oncology Medicine-Oncology

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The Experimental Oncology is an English-language journal that publishes review articles, original contributions, short communications, case reports and technical advances presenting new data in the field of experimental and fundamental oncology. Manuscripts should be written in English, contain original work, which has not been published or submitted for publication elsewhere. It also implies the transfer of the Copyright from the author to “Experimental Oncology”. No part of journal publications may be reproduced, stored in a retrieval system or transmitted in any form or by any means without the prior permission of the publisher.