Nodular Sclerosing Hodgkin Lymphoma With Paraneoplastic Cerebellar Degeneration.

Abstract

Background: There are a variety of paraneoplastic syndromes associated with Hodgkin lymphoma including paraneoplastic cerebellar degeneration (PCD), which is associated with unique autoantibodies, such as anti-Tr antibody. Most of these autoimmune phenomena involve older adult patients with abrupt, acute presentations.

Case presentation: We report an atypical case of a young adult female patient with slow progressive onset of PCD symptoms with subsequent detection and treatment of Hodgkin lymphoma.

Conclusions: Early detection of PCD is critical, as treatment of the underlying malignancy decreases overall morbidity and disability.