Predictive Value of Adenoviral Load for Bronchial Mucus Plugs Formation in Children with Adenovirus Pneumonia.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2022-08-08 eCollection Date: 2022-01-01 DOI:10.1155/2022/9595184

Li Peng, Silan Liu, Tian Xie, Yu Li, Zhuojie Yang, Yongqi Chen, Liangji Deng, Han Huang, Xiaofang Ding, Min Chen, Lin Lin, Sangzi Wei, Lili Zhong

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引用次数: 1

Abstract

Background: The study aimed to explore risk factors for bronchial mucus plugs (BMP) formation in children with adenovirus (AdV) pneumonia.

Methods: A retrospective study was conducted on children with AdV pneumonia who underwent bronchoscopy from January 2019 to December 2019. Children were divided into the BMP group and the control group, depending on whether BMP was formed or not. The clinical information and treatment proposals of the two groups of children were counted and analyzed via multiple logistic regression analysis, ROC curve analysis, and correlation analysis.

Results: Among 453 patients with AdV pneumonia, 185 (40.84%) were in the BMP group. Among all the cases, there were 188 patients with a single AdV infection, including 64 (34.04%) in the BMP group and 124 (65.96%) in the control group. The incidence of dyspnea, poor spirits, mixed infections, and other symptoms in the BMP group was higher than in the control group. Children in the BMP group had a longer heat range. C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer (DD), and AdV load levels were higher in the MBP group. AdV load, Mycoplasma coinfection, DD, heat range, and LDH were independent risk factors for BMP, among which AdV load was the most significant (AUC = 0.819). AdV load was positively correlated with other risk factors, respectively. AdV load and heat range were independent risk factors for BMP patients with a single AdV infection.

Conclusion: AdV load might have important clinical value in predicting BMP development in AdV pneumonia.

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腺病毒载量对腺病毒肺炎患儿支气管粘液塞形成的预测价值。

背景:本研究旨在探讨腺病毒肺炎(AdV)患儿支气管粘液塞(BMP)形成的危险因素。方法:对2019年1月至2019年12月行支气管镜检查的AdV肺炎患儿进行回顾性研究。根据是否形成BMP，将患儿分为BMP组和对照组。对两组患儿的临床资料及治疗方案进行统计分析，采用多元logistic回归分析、ROC曲线分析及相关分析。结果:453例AdV肺炎患者中，BMP组185例(40.84%)。其中，单次AdV感染188例，其中BMP组64例(34.04%)，对照组124例(65.96%)。BMP组呼吸困难、精神不振、混合性感染等症状的发生率均高于对照组。BMP组患儿发热范围较长。c -反应蛋白(CRP)、乳酸脱氢酶(LDH)、d -二聚体(DD)和AdV负荷水平在MBP组较高。AdV载量、支原体合并感染、DD、热范围、LDH是BMP的独立危险因素，其中AdV载量最显著(AUC = 0.819)。AdV负荷与其他危险因素分别呈正相关。AdV负荷和热范围是单一AdV感染的BMP患者的独立危险因素。结论:AdV载量对预测AdV肺炎发生BMP可能具有重要的临床价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.