Risk of Falls in HIV-Infected Patients on Antiretroviral Therapy and Its Associated Factors.

IF 1.5 Q4 INFECTIOUS DISEASES

HIV AIDS-Research and Palliative Care Pub Date : 2022-08-02 eCollection Date: 2022-01-01 DOI:10.2147/HIV.S372204

Edy Rizal Wahyudi, Rizki Febriani Putri, Evy Yunihastuti, Hamzah Shatri

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引用次数: 1

Abstract

Purpose: Fall is one of the geriatric syndromes and a significant public health concern, which causes potentially severe consequences among the elderly. Geriatric syndromes are common among PLHIV and affect younger age than the general population. This study attempted to identify the risk of falls in PLHIV on antiretroviral therapy (ART) and its related factors among older adults with HIV infection.

Methods: This cross-sectional study was conducted from December 2019 to May 2020 among PLHIV aged ≥40 years who received ART for at least 6 months in HIV Integrated Clinic, Cipto Mangunkusumo Hospital, Jakarta. Bivariate and multivariate analyses were performed using Poisson regression with robust estimator using STATA version 12.0.

Results: A total of 102 participants mainly consisted of males (83.3%) with a median age of 45 (IQR 5) years. The risk of fall was detected in 52% of these participants. PLHIV who have history of falls, current CD4 below 200 cells/mm³, and pre-frail-frail status were associated with an increased risk of falls in the future. An LPV/r-based regimen was found to be a protective factors of risk of falls among PLHIV.

Conclusion: History of falls, current CD4 below 200 cells/mm³, and pre-frail and frail status were identified as factors associated with a greater risk of fall among PLHIV.

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接受抗逆转录病毒治疗的hiv感染患者跌倒的风险及其相关因素

目的:跌倒是一种老年综合征，也是一个重大的公共卫生问题，可能对老年人造成严重后果。老年综合征在艾滋病毒感染者中很常见，影响年龄比一般人群小。本研究试图确定艾滋病毒感染老年人接受抗逆转录病毒治疗(ART)后PLHIV下降的风险及其相关因素。方法:本横断面研究于2019年12月至2020年5月在雅加达Cipto Mangunkusumo医院HIV综合诊所接受ART治疗至少6个月的年龄≥40岁的PLHIV患者中进行。双变量和多变量分析使用泊松回归和稳健估计器，使用STATA 12.0版本。结果:102例受试者以男性为主(83.3%)，中位年龄45岁(IQR 5)。在这些参与者中，有52%的人有跌倒的风险。有跌倒史、当前CD4低于200细胞/mm3、体弱多病状态的PLHIV患者与未来跌倒的风险增加有关。以LPV/r为基础的方案被发现是PLHIV患者跌倒风险的保护因素。结论:跌倒史、当前CD4低于200 cells/mm3、体弱前期和体弱状态是PLHIV患者跌倒风险增加的相关因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

HIV AIDS-Research and Palliative Care INFECTIOUS DISEASES-

CiteScore

3.00

自引率

6.70%

发文量

审稿时长

16 weeks

期刊介绍： About Dove Medical Press Dove Medical Press Ltd is part of Taylor & Francis Group, the Academic Publishing Division of Informa PLC. We specialize in the publication of Open Access peer-reviewed journals across the broad spectrum of science, technology and especially medicine. Dove Medical Press was founded in 2003 with the objective of combining the highest editorial standards with the ''best of breed'' new publishing technologies. We have offices in Manchester and London in the United Kingdom, representatives in Princeton, New Jersey in the United States, and our editorial offices are in Auckland, New Zealand. Dr Scott Fraser is our Medical Director based in the UK. He has been in full time clinical practice for over 20 years as well as having an active research interest.