Protective effects of Portulaca oleracea and vitamin E on cardiovascular parameters in rats with subclinical hyperthyroidism.

IF 1.5 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension Pub Date : 2022-10-03 Epub Date: 2022-08-16 DOI:10.1080/10641963.2022.2112209

Mousa-Al-Reza Hadjzadeh, Hadi Khodadadi, Farzaneh Sohrabi, Mahdiyeh Hedayati-Moghadam, Atieh Ghorbani, Sara Hosseinian

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引用次数: 0

Abstract

Introduction: Subclinical hyperthyroidism (SHT) is an endocrine disorder that is associated with abnormalities in heart structure and function. Oxidative stress plays an important role in the pathophysiology of cardiac disorders caused by SHT. Portulaca oleracea (P. Oleracea) is a herbaceous plant with many pharmacologic effects including antioxidant, and anti-inflammatory properties. In the present study, the effects of Portulaca oleracea and vitamin E on the biochemical, hemodynamic, and functional parameters of the cardiac tissue was studied in rats with subclinical hyperthyroidism.

Methods: Fifty-six male rats were divided into seven groups: 1-Control group: daily injection of saline, 2-SHT group: daily injection of levothyroxine sodium (LS) (20 µg/kg), 3- T4+Po groups were given LS and P. oleracea (100, 200, and 400 mg/kg in drinking water), 4- the T4+vit E groups received LS and a daily injection of vitamin E (100 and 200 mg/kg). Cardiac index, systolic blood pressure (SBP), also malondialdehyde and total thiol levels were measured in cardiac tissue.

Results: SBP and maximum dP/dt were significantly increased and minimum dP/dt was significantly decreased in SHT group. In P. oleracea groups, maximum dP/dt were significantly reduced and minimum dP/dt was increased. Malondialdehyde levels and cardiac index in groups receiving vitamin E and P. oleracea were significantly decreased. Maximum dP/dt was decreased in the group receiving LS+vitamin E. Minimum dP/dt was significantly higher in group received LS+ vitamin E.

Conclusion: This study showed that Portulaca oleracea has a positive effect on cardiac dysfunction caused by subclinical hyperthyroidism.

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马齿苋和维生素E对亚临床甲亢大鼠心血管参数的保护作用。

简介:亚临床甲状腺功能亢进(SHT)是一种与心脏结构和功能异常相关的内分泌疾病。氧化应激在SHT所致心脏疾病的病理生理中起重要作用。马齿苋(P. oleracea)是一种具有多种药理作用的草本植物，包括抗氧化和抗炎特性。本研究研究马齿苋和维生素E对亚临床甲亢大鼠心脏组织生化、血流动力学和功能参数的影响。方法:将56只雄性大鼠分为7组:1-对照组:每日注射生理盐水，2-SHT组:每日注射左旋甲状腺素钠(LS)(20µg/kg)， 3- T4+Po组给予LS和马根苋(100、200、400 mg/kg饮水)，4- T4+维生素E组给予LS和维生素E(100、200 mg/kg)。测量心脏指数、收缩压(SBP)、丙二醛和总硫醇水平。结果:SHT组患者收缩压、最大dP/dt显著升高，最小dP/dt显著降低。马齿苋组最大dP/dt显著降低，最小dP/dt显著升高。维生素E和马齿苋组丙二醛水平和心脏指数显著降低。LS+维生素e组最大dP/dt值降低，LS+维生素e组最小dP/dt值显著高于LS+维生素e组。结论:马齿苋对亚临床甲亢性心功能障碍有积极作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Hypertension 医学-外周血管病

CiteScore

3.90

自引率

0.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical and Experimental Hypertension is a reputable journal that has converted to a full Open Access format starting from Volume 45 in 2023. While previous volumes are still accessible through a Pay to Read model, the journal now provides free and open access to its content. It serves as an international platform for the exchange of up-to-date scientific and clinical information concerning both human and animal hypertension. The journal publishes a wide range of articles, including full research papers, solicited and unsolicited reviews, and commentaries. Through these publications, the journal aims to enhance current understanding and support the timely detection, management, control, and prevention of hypertension-related conditions. One notable aspect of Clinical and Experimental Hypertension is its coverage of special issues that focus on the proceedings of symposia dedicated to hypertension research. This feature allows researchers and clinicians to delve deeper into the latest advancements in this field. The journal is abstracted and indexed in several renowned databases, including Pharmacoeconomics and Outcomes News (Online), Reactions Weekly (Online), CABI, EBSCOhost, Elsevier BV, International Atomic Energy Agency, and the National Library of Medicine, among others. These affiliations ensure that the journal's content receives broad visibility and facilitates its discoverability by professionals and researchers in related disciplines.