Laboratory policies and practices for thyroid function tests in Croatia: survey on behalf of Working Group for Laboratory Endocrinology of the Croatian Society of Medical Biochemistry and Laboratory Medicine.

IF 3.8 3区 医学 Q1 MEDICAL LABORATORY TECHNOLOGY
Biochemia Medica Pub Date : 2022-10-01 Epub Date: 2022-08-05 DOI:10.11613/BM.2022.030702
Adriana Bokulić, Ivana Zec, Sanja Goreta, Nora Nikolac Gabaj, Marija Kocijančić, Tihana Serdar Hiršl, Anamarija Đuras, Mateja Troha, Lada Stanišić, Daniela Šupe-Domić, Sanda Jelisavac Ćosić, Koraljka Đurić, Domagoj Marijančević, Marija Siter Kuprešanin, Iva Lukić, Alenka Pezo, Jasna Leniček Krleža
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引用次数: 0

Abstract

Introduction: Laboratory plays important part in screening, diagnosis, and management of thyroid disorders. The aim of this study was to estimate current laboratory preanalytical, analytical and postanalytical practices and policies in Croatia.

Materials and methods: Working Group for Laboratory Endocrinology of the Croatian Society of Medical Biochemistry and Laboratory Medicine designed a questionnaire with 27 questions and statements regarding practices and protocols in measuring thyroid function tests. The survey was sent to 111 medical biochemistry laboratories participating in external quality assurance scheme for thyroid hormones organized by Croatian Centre for Quality Assessment in Laboratory Medicine. Data is presented as absolute numbers and proportions.

Results: Fifty-three participants returned the questionnaire. Response rate varied depending on question, yielding a total survey response rate of 46-48%. All respondents perform thyroid stimulating hormone (TSH). From all other thyroid tests, most performed is free thyroxine (37/53) and least TSH-stimulating immunoglobulin (1/53). Laboratories are using nine different immunoassay methods. One tenth of laboratories is verifying manufacturer's declared limit of quantification for TSH and one third is verifying implemented reference intervals for all performed tests. Most of laboratories (91%) adopt the manufacturer's reference interval for adult population. Reference intervals for TSH are reported with different percentiles (90, 95 or 99 percentiles).

Conclusion: This survey showed current practices and policies in Croatian laboratories regarding thyroid testing. The results identified some critical spots and will serve as a foundation in creating national guidelines in order to harmonize laboratory procedures in thyroid testing in Croatia.

克罗地亚甲状腺功能测试的实验室政策和做法:代表克罗地亚医学生物化学和实验室医学学会实验室内分泌学工作组进行的调查。
实验室在甲状腺疾病的筛查、诊断和治疗中起着重要的作用。这项研究的目的是估计克罗地亚目前的实验室分析前、分析后和分析后的做法和政策。材料和方法:克罗地亚医学生物化学和实验室医学学会实验室内分泌学工作组设计了一份问卷,其中有27个问题和关于测量甲状腺功能测试的做法和规程的说明。该调查已发送给参加克罗地亚实验室医学质量评估中心组织的甲状腺激素外部质量保证计划的111个医学生物化学实验室。数据以绝对数字和比例表示。结果:53名参与者进行了问卷调查。回应率因问题而异,总调查回应率为46-48%。所有应答者均进行促甲状腺激素(TSH)检测。在所有其他甲状腺检查中,检测游离甲状腺素最多(37/53),促tsh免疫球蛋白最少(1/53)。实验室正在使用九种不同的免疫测定方法。十分之一的实验室正在核实制造商所宣布的TSH定量限度,三分之一的实验室正在核实所有已进行的测试的实施参考区间。大多数实验室(91%)对成年人群采用制造商的参考区间。TSH的参考区间以不同的百分位数(90,95或99百分位数)报告。结论:这项调查显示了克罗地亚实验室关于甲状腺检测的现行做法和政策。结果确定了一些关键的点,并将作为制定国家准则的基础,以便在克罗地亚统一甲状腺检测的实验室程序。
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来源期刊
Biochemia Medica
Biochemia Medica 医学-医学实验技术
CiteScore
5.50
自引率
3.00%
发文量
70
审稿时长
>12 weeks
期刊介绍: Biochemia Medica is the official peer-reviewed journal of the Croatian Society of Medical Biochemistry and Laboratory Medicine. Journal provides a wide coverage of research in all aspects of clinical chemistry and laboratory medicine. Following categories fit into the scope of the Journal: general clinical chemistry, haematology and haemostasis, molecular diagnostics and endocrinology. Development, validation and verification of analytical techniques and methods applicable to clinical chemistry and laboratory medicine are welcome as well as studies dealing with laboratory organization, automation and quality control. Journal publishes on a regular basis educative preanalytical case reports (Preanalytical mysteries), articles dealing with applied biostatistics (Lessons in biostatistics) and research integrity (Research integrity corner).
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