АNTIMETASTATIC EFFECT OF B. SUBTILIS IMV B-7724 LECTIN OBSERVED IN LEWIS LUNG CARCINOMA MODEL.

Q3 Medicine

Experimental oncology Pub Date : 2022-08-01 DOI:10.32471/exp-oncology.2312-8852.vol-44-no-2.17914

N I Fedosova, T V Symchych, N L Cheremshenko, A V Chumak, E V Koval, О М Karaman, I M Voyejkova

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引用次数: 0

Abstract

Aim: To study the antitumor and antimetastatic effects of B. subtilis IMV B-7724 lectin used in neoadjuvant and adjuvant settings in vivo.

Materials and methods: Studies were performed on C57Bl/6J mice; Lewis lung carcinoma (LLC) was used as an experimental tumor. В. subtilis ІМV В-7724 lectin was administered to tumor-bearing mice or to mice which underwent surgical resection of the primary tumor. The lectin was injected subcutaneously, 10 times, at a single dose of 5 or 1 mg/kg of body weight. The standard indicators of tumor growth and metastasis were evaluated.

Results: Independently of the application settings, the lectin at a dose of 1 mg/kg of b.w. caused more pronounced effect than at a dose of 5 mg/kg of b.w. The administration of B. subtilis IMV B-7724 lectin to the mice with LLC in neoadjuvant setting did not cause notable antitumor effect but led to a significant decrease in the number and volume of lung metastases. The lectin administration in adjuvant setting significantly inhibited metastasis: the metastasis inhibition index reached 63.0% and 100% in the mice treated with the lectin at a dose of 5 mg/kg and 1 mg/kg respectively. The mean survival time of the treated animals significantly increased.

Conclusion: A pronounced antimetastatic effect of B. subtilis IMV B-7724 lectin administered in an adjuvant setting was demonstrated.

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Аntimetastatic枯草芽孢杆菌imv b-7724凝集素在lewis肺癌模型中的作用。

目的:研究枯草芽孢杆菌IMV B-7724凝集素在体内新佐剂和佐剂中的抗肿瘤和抗转移作用。材料与方法:C57Bl/6J小鼠;Lewis肺癌(LLC)作为实验肿瘤。В。枯草杆菌ІМV В-7724凝集素给予荷瘤小鼠或手术切除原发肿瘤的小鼠。将凝集素皮下注射10次，单次剂量为5或1 mg/kg体重。评估肿瘤生长和转移的标准指标。结果:与应用环境无关，枯草芽孢杆菌IMV B-7724凝集素在1 mg/kg体重下的作用比5 mg/kg体重下的作用更明显。在新辅助环境下，枯草芽孢杆菌IMV B-7724凝集素对LLC小鼠的抗肿瘤作用不显著，但导致肺转移瘤的数量和体积显著减少。在佐剂环境下给予凝集素显著抑制转移:5 mg/kg和1 mg/kg剂量的凝集素对小鼠的转移抑制指数分别达到63.0%和100%。治疗组动物的平均生存时间明显延长。结论:枯草芽孢杆菌IMV B-7724凝集素在佐剂环境中具有明显的抗转移作用。

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来源期刊

Experimental oncology Medicine-Oncology

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The Experimental Oncology is an English-language journal that publishes review articles, original contributions, short communications, case reports and technical advances presenting new data in the field of experimental and fundamental oncology. Manuscripts should be written in English, contain original work, which has not been published or submitted for publication elsewhere. It also implies the transfer of the Copyright from the author to “Experimental Oncology”. No part of journal publications may be reproduced, stored in a retrieval system or transmitted in any form or by any means without the prior permission of the publisher.