Mitochondrial DNA: Consensuses and Controversies.

DNA Pub Date : 2022-06-01 Epub Date: 2022-06-10 DOI:10.3390/dna2020010
Inna Shokolenko, Mikhail Alexeyev
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引用次数: 8

Abstract

In the course of its short history, mitochondrial DNA (mtDNA) has made a long journey from obscurity to the forefront of research on major biological processes. mtDNA alterations have been found in all major disease groups, and their significance remains the subject of intense research. Despite remarkable progress, our understanding of the major aspects of mtDNA biology, such as its replication, damage, repair, transcription, maintenance, etc., is frustratingly limited. The path to better understanding mtDNA and its role in cells, however, remains torturous and not without errors, which sometimes leave a long trail of controversy behind them. This review aims to provide a brief summary of our current knowledge of mtDNA and highlight some of the controversies that require attention from the mitochondrial research community.

Abstract Image

Abstract Image

线粒体DNA:共识和争议。
在其短暂的历史过程中,线粒体DNA (mtDNA)经历了漫长的旅程,从默默无闻到主要生物过程的研究前沿。在所有主要疾病组中都发现了mtDNA的改变,其意义仍然是深入研究的主题。尽管取得了显著的进展,但我们对mtDNA生物学的主要方面,如其复制、损伤、修复、转录、维持等的理解仍令人沮丧地有限。然而,更好地理解mtDNA及其在细胞中的作用的道路仍然是痛苦的,并非没有错误,有时会留下一长串争议。这篇综述的目的是提供我们目前对线粒体dna的知识的简要总结,并强调一些需要引起线粒体研究界注意的争议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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DNA
DNA
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