Expression and prognostic potential of TMEM204: a pan-cancer analysis.

IF 1.1 Q4 ONCOLOGY
International journal of clinical and experimental pathology Pub Date : 2022-07-15 eCollection Date: 2022-01-01
Zicheng Zhen, Minghao Li, Muyan Zhong, Jiaqi Liu, Wendu Huang, Liqun Ye
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引用次数: 0

Abstract

TMEM204 (Transmembrane Protein 204) is a member of the TMEM family that regulates cell function and angiogenesis. Previous studies showed that TMEM204 is related to pancreatic cancer, but its roles in other cancers remain unknown. To reveal this relationship, we conducted a pan-cancer analysis by several online databases. The expression of TMEM204 was analyzed by Oncomine and Tumor Immune Estimation Resource2.0 (TIMER2.0). The prognostic potential of TMEM204 was evaluated by the GEPIA2, UALCAN, and Oncolnc. The methylation level of gene expression was analyzed by UALCAN, and the relationship between cancer and immune invasion was displayed by TIMER2.0. The Protein-Protein Interactions Network and functional analysis of TMEM204 and its related genes were conducted by STRING and Webgestalt. We found that TMEM204 expression was up-regulated and correlated with prognosis in multiple cancers. In liver hepatocellular carcinoma (LIHC), high TMEM204 expression was associated with a good prognosis, and with high infiltrating levels of CD8+ T and CD4+ T cells, macrophages, neutrophils, and myeloid dendritic cells. In addition, the methylation level in LIHC was higher than in normal tissues. p53 signaling pathway and Fanconi anemia pathway were implicated by KEGG pathway analysis. These results indicate that TMEM204 is associated with the prognosis, methylation, and immune invasion of cancers, especially LIHC. TMEM204 may act as a prognostic marker of LIHC and its role in other cancers should be studied.

Abstract Image

TMEM204的表达和预后潜力:一项泛癌症分析。
TMEM204(跨膜蛋白204)是调节细胞功能和血管生成的TMEM家族成员。先前的研究表明TMEM204与胰腺癌有关,但其在其他癌症中的作用尚不清楚。为了揭示这种关系,我们通过几个在线数据库进行了一项泛癌症分析。采用Oncomine and Tumor Immune Estimation Resource2.0 (TIMER2.0)软件分析TMEM204的表达情况。TMEM204的预后潜力由GEPIA2、UALCAN和Oncolnc进行评估。用UALCAN分析基因表达的甲基化水平,用TIMER2.0显示肿瘤与免疫侵袭的关系。通过STRING和Webgestalt对TMEM204及其相关基因进行蛋白-蛋白相互作用网络和功能分析。我们发现TMEM204在多种癌症中表达上调并与预后相关。在肝细胞癌(LIHC)中,TMEM204的高表达与良好的预后相关,并且与CD8+ T和CD4+ T细胞、巨噬细胞、中性粒细胞和骨髓树突状细胞的高浸润水平相关。此外,LIHC的甲基化水平高于正常组织。KEGG通路分析涉及p53信号通路和Fanconi贫血通路。这些结果表明,TMEM204与癌症,特别是LIHC的预后、甲基化和免疫侵袭有关。TMEM204可能作为LIHC的预后标志物,其在其他癌症中的作用有待进一步研究。
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来源期刊
自引率
0.00%
发文量
42
审稿时长
1 months
期刊介绍: The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.
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