ALDH2 gene polymorphism is associated with fitness in the elderly Japanese population.

IF 3.1 4区医学 Q1 Social Sciences

Journal of Physiological Anthropology Pub Date : 2022-11-05 DOI:10.1186/s40101-022-00312-1

Kathleen Yasmin De Almeida, Mika Saito, Hiroki Homma, Yukina Mochizuki, Aoto Saito, Minoru Deguchi, Ayumu Kozuma, Takanobu Okamoto, Koichi Nakazato, Naoki Kikuchi

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引用次数: 3

Abstract

Purpose: The aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism, which is exclusive to the Asian population, is related to many diseases. A high reactive oxygen species production in mitochondria, and low muscle strength in athletes and non-athletes, has been observed, as our previous study demonstrated. The purpose of this research was to investigate the influence of ALDH2 rs671 on the loss of muscle strength with aging and replicate our previous study in non-athletes.

Methods: Healthy Japanese individuals (n = 1804) aged 23-94 years were genotyped using DNA extracted from saliva. Muscle strength was assessed using grip strength and chair stand test (CST). The interaction between age and genotypes was analyzed by two-way analysis of covariance (ANCOVA) adjusted for sex, body mass index (BMI), and exercise habit.

Results: Individuals aged ≧55 with the AA genotype had a lower performance than those with the GG + GA genotype in the grip strength test (28.1 ± 9.1 kg vs. 29.1 ± 8.3 kg, p = 0.021). There was an interaction between age and genotype, where individuals with ≧55 years old AA genotype had a higher loss of strength compared to GG + GA genotypes in the CST (0.025). No interaction in other models and no sex differences were found.

Conclusion: This study replicated previous results of the relationship between the AA genotype with lower muscle strength and as a novelty showed that this genotype is associated with a higher age-related loss of strength.

Abstract Image

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ALDH2基因多态性与日本老年人健康状况相关。

目的:醛脱氢酶2 (ALDH2) rs671多态性是亚洲人群所独有的，与多种疾病有关。正如我们之前的研究所证明的那样，已经观察到运动员和非运动员线粒体中活性氧含量高，肌肉力量低。本研究的目的是探讨ALDH2 rs671对随着年龄增长肌肉力量丧失的影响，并在非运动员中重复我们之前的研究。方法:用唾液提取的DNA对1804名23 ~ 94岁的健康日本人进行基因分型。肌肉力量评估采用握力和椅子站立测试(CST)。采用经性别、体重指数(BMI)和运动习惯校正的双向协方差分析(ANCOVA)分析年龄与基因型之间的相互作用。结果:≥55岁AA基因型个体握力测试成绩低于GG + GA基因型个体(28.1±9.1 kg比29.1±8.3 kg, p = 0.021)。年龄与基因型之间存在交互作用，在CST中，≥55岁AA基因型个体的强度损失高于GG + GA基因型个体(0.025)。在其他模型中没有发现相互作用，也没有发现性别差异。结论:该研究重复了先前AA基因型与较低肌肉力量之间关系的结果，并且作为一个新颖的发现，该基因型与较高的年龄相关的力量丧失有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Physiological Anthropology Social Sciences-Human Factors and Ergonomics

CiteScore

4.80

自引率

6.50%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Physiological Anthropology (JPA) is an open access, peer-reviewed journal that publishes research on the physiological functions of modern mankind, with an emphasis on the physical and bio-cultural effects on human adaptability to the current environment. The objective of JPA is to evaluate physiological adaptations to modern living environments, and to publish research from different scientific fields concerned with environmental impact on human life. Topic areas include, but are not limited to: environmental physiology bio-cultural environment living environment epigenetic adaptation development and growth age and sex differences nutrition and morphology physical fitness and health Journal of Physiological Anthropology is the official journal of the Japan Society of Physiological Anthropology.