VALIDATION OF A PANEL OF BIOMARKERS ASSOCIATED WITH AGGRESSIVE PHENOTYPE OF ENDOMETRIOID CARCINOMA OF ENDOMETRIUM.

Q3 Medicine

Experimental oncology Pub Date : 2022-11-01 DOI:10.32471/exp-oncology.2312-8852.vol-44-no-3.18513

L G Buchynska, N P Iurchenko, I P Nesina, N M Glushchenko

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引用次数: 1

Abstract

Aim: To evaluate the prognostic significance of a panel of biomarkers for the identification of a highly malignant molecular subtype of endometrioid carcinoma of the endometrium (ECE).

Materials and methods: The expression of a number of markers (CD24, CD44, E2F1, FOXP3, Her2/neu, p21WAF1/CIP1, p53, β-catenin, vimentin, Е-cadherin, с-Myc, cyclins D1 and Е1) was determined by the immunohistochemical method in the samples of resected tumors of 127 patients with ECE of I-II stage. The Kullback method and the PanelomiX web tool were used to assess the informativeness and identify the aggressive subtype of ECE. The associative relationships of the studied markers were determined using the STRING v11 database.

Results: The study of the prognostic significance of a number of biomarkers in ECE has revealed the informativeness, high specificity and sensitivity (> 95%) of the р53+FOXP3-c-Myc+ phenotype, which is associated with a more aggressive tumor process. Bioinformatics analysis confirmed the correlative relationships between p53, FOXP3 and c-Myc, which are significant prognostic markers associated with cancer progression in ECE patients.

Conclusions: The identified molecular phenotype of ECE (р53+FOXP3-c-Myc+) has differential and prognostic significance and objectively reflects a highly malignant subtype of this form of cancer.

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一组与子宫内膜癌侵袭性表型相关的生物标志物的验证。

目的:评价一组生物标志物在鉴别子宫内膜高恶性分子亚型子宫内膜样癌(ECE)中的预后意义。材料与方法:采用免疫组化方法检测127例I-II期ECE患者切除肿瘤标本中CD24、CD44、E2F1、FOXP3、Her2/neu、p21WAF1/CIP1、p53、β-catenin、vimentin、Е-cadherin、 - myc、cyclins D1、Е1等标志物的表达。使用Kullback方法和PanelomiX网络工具评估信息量并确定ECE的侵袭性亚型。使用STRING v11数据库确定所研究标记的关联关系。结果:通过对ECE中多个生物标志物的预后意义的研究，揭示了其信息丰富、高特异性和敏感性(> 95%)，且其表型与更具有侵袭性的肿瘤过程相关。生物信息学分析证实了p53、FOXP3和c-Myc之间的相关关系，它们是ECE患者癌症进展的重要预后标志物。结论:所鉴定的ECE分子表型(53.53 +FOXP3-c-Myc+)具有鉴别和预后意义，客观反映了该癌的高度恶性亚型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental oncology Medicine-Oncology

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The Experimental Oncology is an English-language journal that publishes review articles, original contributions, short communications, case reports and technical advances presenting new data in the field of experimental and fundamental oncology. Manuscripts should be written in English, contain original work, which has not been published or submitted for publication elsewhere. It also implies the transfer of the Copyright from the author to “Experimental Oncology”. No part of journal publications may be reproduced, stored in a retrieval system or transmitted in any form or by any means without the prior permission of the publisher.